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CompletedNCT03646942Updated Jul 18, 2019

The Role of Low Level Laser Therapy in Acceleration of Teeth Alignment in Lingual Orthodontic Patients

An interventional study of low level laser therapy and Lingual Orthodontics in Malocclusion, Angle Class I and Crowding, sponsored by Damascus University. Completed at 1 site in Syrian Arab Republic. Open to participants aged 17 Years to 27 Years. Per ClinicalTrials.gov, last updated 2019-07-18.

Sponsored by Damascus University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
17 Years to 27 Years
Sex
All
01

Study summary

We will treat patients with class I malocclusion who have moderate crowding (4-6 mm) according to Little's irregularity index and asses the efficacy of low level laser therapy in accelerating orthodontic tooth movement .

There is two groups :

  1. treated with Low level laser therapy (LLLT)
  2. treated traditionally without any irradiation Patients will be randomly allocated in any group and all data will be collected through photographs when leveling and alignment completed.

Also pain levels will be assessed using numeric rating scale to compare between the two groups and if laser really can relief pain or not .

Read the detailed description

The time of orthodontic treatment is considered to be one of the most concerns for patients. The study will investigate the effect of low level laser therapy on the speed of orthodontic tooth movement during the correction of moderately crowded anterior upper teeth using lingual orthodontic appliance.

The study will be accomplished with two arms, the first is LLLT arm and the other is the control arm without any active intervention.

Low level laser with a wave length of 830 nm, output of 150 mW, energy of 2 J per point and application time of 15 seconds per point will be applied on each tooth of the six upper incisors according to this protocol: the root will be divided into 2 halves; gingival and cervical. Laser will be applied in the center of each half from both the buccal and palatal sides which means 4 application points and a total energy of 8 j per each tooth.

Within the limits of our knowledge, this is the first study in the world that will study acceleration of orthodontic tooth movement with lingual orthodontic .

02

Conditions studied

  • Malocclusion, Angle Class I
  • Crowding
03

Who can participate

Ages eligible
17 Years to 27 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Class I malocclusion with mild to moderate crowding
  • Old between 17-27 years
  • Good oral hygiene
  • Patients should be fit and well
  • 4-6 mm crowding in upper incisors according to Little's index
  • Enough clinical crowns length

Exclusion criteria

Exclusion Criteria:

  • Patients who had an old orthodontic treatment
  • People who have any drug or disease affect orthodontic movement
  • Any contraindication for orthodontic treatment
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
36 participants (actual)

Study arms

  • Active comparator
    Lingual orthodontics

    Patients will be treated with lingual braces without being irradiation with low level laser therapy. Treatment will go forward in the normal manner. Archwires will be changed in the traditional way.

    Radiation: low level laser therapy · Device: Lingual Orthodontics

  • Experimental
    Low level laser therapy

    Patients will be subjected to low level laser therapy during their orthodontic treatment using lingual braces.

    Radiation: low level laser therapy

Interventions

  • Radiationlow level laser therapy

    low level laser therapy will be used in order to induce tooth movement. low level laser with a wave length of 830 nm, output of 150 mw, energy of 2 j per point and application time of 15 seconds per point will be applied on each tooth of the six upper incisors according to this protocol: the root will be divided into 2 halves; gingival and cervical. Laser will be applied in the center of each half from both the buccal and palatal sides which means 4 application points and a total energy of 8 Joules/each tooth.

    Also known as: LLLT, soft tissue laser

  • DeviceLingual Orthodontics

    Lingual braces will be used to conduct the orthodontic treatment of patients with moderate level of crowding on the upper dental arch.

05

What researchers measure

Primary outcomes

  1. Duration of tooth alignment

    Days required to complete tooth alignment will be counted.

    Time frame: When the treatment is completed (i.e. tooth alignment is achieved) and this is expected to take 100 days on average

  2. Change in Tooth Alignment at one month

    Little's Index of Irregularity will be measured at 30 days after the onset of treatment. This index is measured on intraoral photographs of patients' teeth. The value obtained will be compared to the value obtained at the beginning of treatment.

    Time frame: T1: one day before the beginning of treatment; T2: at 30 days after the onset of treatment.

  3. Change in Tooth Alignment at two months

    Little's Index of Irregularity will be measured at 60 days after the onset of treatment. This index is measured on intraoral photographs of patients' teeth. The value obtained will be compared to the value obtained at the beginning of treatment.

    Time frame: T1: one day before the beginning of treatment; T2: at 60 days after the onset of treatment.

  4. Change in Tooth Alignment at the end of Alignment Stage

    Little's Index of Irregularity will be measured when a complete alignment is achieved; this is expected between 90 to 120 days after the onset of treatment. This index is measured on intraoral photographs of patients' teeth. The value obtained will be compared to the value obtained at the beginning of treatment.

    Time frame: T1: one day before the beginning of treatment; T2: when alignment of teeth is complete and this is expected to occur within 90 - 120 days

Secondary outcomes

  1. Change in the levels of pain and discomfort

    Assessment will be performed using questionnaires via numeric rating scales (NRS) These levels will be assessed during the first stage of leveling and alignment.

    Time frame: T1: 10 minutes following the insertion of the first wire in the beginning of treatment; T2: at 24 hours post-commencement; T3: at 48 hours; T4: at 72 hours following the placement of primary archwire

  2. Change in Patients' Acceptance

    Assessment will be performed using a standardized questionnaire

    Time frame: (1) one day following the beginning of the treatment, (2) after one week of the beginning of treatment, (3) after 4 weeks, (5) at the end the alignment stage which is expected to occur within 3 to 4 months

06

Study locations

1 site
  • Orthodontic Department, University of Damascus Dental School
    Damascus, DM20AM18, Syrian Arab Republic
07

References and documents

Publications

  • AlSayed Hasan MMA, Sultan K, Hamadah O. Low-level laser therapy effectiveness in accelerating orthodontic tooth movement: A randomized controlled clinical trial. Angle Orthod. 2017 Jul;87(4):499-504. doi: 10.2319/062716-503.1. Epub 2016 Nov 21. Erratum In: Angle Orthod. 2018 Jan;88(1):125. doi: 10.2319/0003-3219-88.1.125. PubMed 27869476 ↗
  • Khattab TZ, Farah H, Al-Sabbagh R, Hajeer MY, Haj-Hamed Y. Speech performance and oral impairments with lingual and labial orthodontic appliances in the first stage of fixed treatment. Angle Orthod. 2013 May;83(3):519-26. doi: 10.2319/073112-619.1. Epub 2012 Oct 18. PubMed 23075062 ↗
  • Fritz U, Diedrich P, Wiechmann D. Lingual technique--patients' characteristics, motivation and acceptance. Interpretation of a retrospective survey. J Orofac Orthop. 2002 May;63(3):227-33. doi: 10.1007/s00056-002-0124-3. English, German. PubMed 12132310 ↗
  • Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis. J Dent. 2014 Oct;42(10):1300-19. doi: 10.1016/j.jdent.2014.07.013. Epub 2014 Jul 27. PubMed 25072362 ↗
  • Cruz DR, Kohara EK, Ribeiro MS, Wetter NU. Effects of low-intensity laser therapy on the orthodontic movement velocity of human teeth: a preliminary study. Lasers Surg Med. 2004;35(2):117-20. doi: 10.1002/lsm.20076. PubMed 15334614 ↗
  • Camacho AD, Velasquez Cujar SA. Dental movement acceleration: Literature review by an alternative scientific evidence method. World J Methodol. 2014 Sep 26;4(3):151-62. doi: 10.5662/wjm.v4.i3.151. eCollection 2014 Sep 26. PubMed 25332914 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03646942
Lead sponsor
Damascus University
Responsible party
Sponsor
First posted
Aug 24, 2018
Start date
Jun 15, 2017
Primary completion
Oct 1, 2018
Completion
Feb 1, 2019
Last update
Jul 18, 2019

Study contacts

Mohammad Y Hajeer, DDS MSc PhD
study chair · Associate Professor of Orthodontics, University of Damascus Dental School, SYRIA
Wael Al-Rasheed Omer, DDS
principal investigator · MSc student in Orthodontics, University of Damascus Dental School, Damascus, SYRIA
Wael Mahdi, DDS MSc PhD
study director · Associate Professor of Periodontics, University of Damascus Dental School, Damascus, SYRIA

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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