An interventional study of Cognitive training and Control Condition in Vascular Diseases, sponsored by São Paulo State University. Active, not recruiting at 1 site in Brazil. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-28.
Sponsored by São Paulo State University · Not applicable, Interventional, and Treatment
The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke
The study will investigate the effects of two cognitive training strategies on behavior, neural correlates and functional connectivity of patients with vascular lesions. The first strategy is associated to the ability to apply efficient organizational semantic category strategy to a list of words. This strategy will be trained in activities similar to everyday life activities. There will be in total 5 sessions, two for measuring the generalization effects before and after training and three sessions to apply the semantic strategy in order to improve encoding and episodic memory performance. The second strategy is related to the ability to remember face-names and the strategy will involve the identification of a salient face feature, creation of a nickname and association of the nickname to the real name. There will be 5 sessions in total, two for measuring the generalization effects before and after training and three sessions to apply the face-name association strategy in order to improve encoding and episodic memory performance. These two cognitive training procedures will be carried out in two separate moments. Before and after each procedure all participants will be examined by functional MRI during resting state and during a active task using a memory encoding paradigm. The same procedure will be carried out with normal control participants.
694 studies on the registry are indexed under Vascular Diseases; 128 are open to participants now.
This study's enrollment of 30 is below the median of 96 across 419 interventional studies indexed under Vascular Diseases.
Browse Vascular Diseases studies →São Paulo State University is the lead sponsor of 34 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Semantic categorization training sessions
Behavioral: Cognitive training
Five sessions of behavioral control condition with information and education
Behavioral: Control Condition
Five sessions of semantic strategy training and face-name association training
Five sessions of active control information and education
Change from baseline memory performance at 6 months
Hopkins Verbal Learning Test (episodic memory test total immediate score 48 and delayed score12) and fMRI active task (news recall immediate and delayed score 12)
Time frame: up to 24 weeks after intervention
Change from baseline everyday life activity performance at 6 months
Generalization questionnaire (questions on difficulties in everyday memory total score 12)
Time frame: up to 24 weeks of intervention
Plan to share: No
Ran from Jan 2015 to primary completion in Feb 2018, 36 months.
Of 103 non-industry interventional studies with no phase under Vascular Diseases, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 57. This study's 36 months is above that.
Counting every sponsor, half of 147 studies reached it within 33 months; a quarter within 19 and three quarters within 57.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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São Paulo State University