An interventional study of Visual Memory Training and Alphabet search in Mild Cognitive Impairment, sponsored by São Paulo State University. Active, not recruiting at 1 site in Brazil. Open to participants aged 60 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-24.
Sponsored by São Paulo State University · Not applicable, Interventional, and Treatment
The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls (HE). MCI patients will be grouped according to biomarkers (PET PIB).
We will include 40 subjects with amnestic mild cognitive impairment (MCI) multiple domain clinical diagnostic, over 60 years old, recruited through the outpatient clinic of University of Sao Paulo General Hospital. We will also include 20 healthy subjects, over 60 years old, recruited in the community. All the participants will be evaluated by neurologists specialized in cognitive neurology and subjected to a neuropsychological assessment. The 40 participants with MCI and 20 healthy subjects will receive 6 sessions of visual imaging training. After this first study, they will receive cognitive training with alphabet search training. This will be a longitudinal study. MCI patients will be grouped according to biomarkers (PET PIB).
3,872 studies on the registry are indexed under Cognitive Dysfunction; 1,119 are open to participants now.
This study's planned enrollment of 60 is close to the median of 64 across 2,794 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →São Paulo State University is the lead sponsor of 34 studies on the registry; 4 are open to participants now.
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Participants will receive visual imaging training to facilitate learning of written information. Intervention: Visual Imaging Training in individual sessions
Behavioral: Visual Memory Training · Behavioral: Alphabet search
In the first phase of the study all participants will receive visual memory training. In the second phase they will receive alphabetic search training
Results from task performance in functional magnetic resonance imaging (fMRI)
fMRI behavioral performance
Time frame: Baseline, after CT, and 12 months later
Changes in cognitive measures and brain activation
Logical Memory Test I and II, RAVLT I e II, brain activity, generalization tasks
Time frame: Baseline, after CT e 12 months follow-up
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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São Paulo State University