Status unknownNCT03607981SR-SCADUpdated Aug 2, 2018

Spanish Registry on Spontaneous Coronary Artery Dissection

An observational study in Spontaneous Coronary Artery Dissection, sponsored by Spanish Society of Cardiology. Status unknown at 37 sites in Spain. Per ClinicalTrials.gov, last updated 2018-08-02.

Sponsored by Spanish Society of Cardiology · Observational

The sponsor has not verified this record recently (last verified Jul 2018), so the status shown — last known as Recruiting — may be out of date.

Study type: Observational
Model: Case-only
Time perspective: Prospective
Enrollment: 300
Sex: All

Study summary

Multicenter observational prospective registry, Spanish nationwide-based, of consecutive patients diagnosed with Spontaneous Coronary Artery Dissection (SCAD)

Read the detailed description

Multicenter prospective registry on patients with diagnosis of Spontaneous Coronary Artery Dissection (SCAD). Spanish nationwide based, the aims of the current registry are:

To analyze predisposing factors, potential triggers and associated pathologies of patients presenting with SCAD.
To study the clinical and angiographic presentation of these patients.
To analyze the value of intracoronary diagnostic techniques (OCT, IVUS) and non-invasive imaging techniques in the diagnosis of this pathology.
To better understand the in-hospital clinical evolution and the response to medical treatment or revascularization in these challenging patients, taking into account the angiographic or intravascular imaging morphological characteristics of SCAD and the treatment applied.
To analyze its long-term clinical evolution (adverse cardiovascular events, including recurrence of SCAD).
To identify those factors directly related to prognostic and risk of recurrence.

Conditions studied

Spontaneous Coronary Artery Dissection

Browse trials for

In context

Aortic Dissection

385 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.

This study's planned enrollment of 300 is above the median of 182 across 179 observational studies indexed under Aortic Dissection.

Browse Aortic Dissection studies →

Lead sponsor

Spanish Society of Cardiology is the lead sponsor of 23 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Non-probability sample

Study population

Consecutive patients with a novel diagnosis of Spontaneous Coronary Artery Dissection (SCAD) that meet the inclusion/exclusion criteria.

Inclusion criteria

Those consecutive patients with a novel diagnosis of Spontaneous Coronary Artery Dissection (SCAD) that, after careful information, accepted to sign the informed consent form.

Exclusion criteria

Exclusion Criteria:

Those patients unable to provide informed consent.

Study design

Observational model: Case-only
Time perspective: Prospective
Enrollment: 300 participants (estimated)
Target follow-up: 3 Years
Patient registry: Yes

What researchers measure

Primary outcomes

Predictors of adverse events
Clinical, angiographic and imaging predictors of adverse events during follow-up
Time frame: 3 years

Secondary outcomes

Predictors of recurrences
Predictors of recurrences of SCAD at follow-up
Time frame: 3 years

Study locations

37 of 37 sites recruiting

Complexo Universitario Hospitalario de Santiago
Santiago de Compostela, A Coruña 15006, Spain
- Belen Cid Alvarez, MD · Contact · belcid77@hotmail.com
Recruiting
Hospital Central de Asturias
Oviedo, Asturias 33006, Spain
- Cesar Morís, MD · Contact · cesarmoris@gmail.com
Recruiting
Hospital Universitari de Bellvitge
L´Hospitalet de Llobregat, Barcelona 08907, Spain
- Gerard Roura Ferrer, MD · Contact · groura@bellvitgehospital.cat
Recruiting
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria 39008, Spain
- Gabriela Veiga, MD · Contact · gveigafernandez@gmail.com
Recruiting
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid 28222, Spain
- Arturo Garcia-Touchard, MD · Contact · agtouchard@gmail.com
Recruiting
Hospital Universitario de Canarias
San Cristobal de La Laguna, Santa Cruz De Tenerife 38320, Spain
- Francisco Bosa Ojeda, MD · Contact · franbosa@ull.edu.es
Recruiting
Hospital Galdakao-Usansolo
Galdakao, Vizcaya 48960, Spain
- Jose Ramón Rumoroso, MD · Contact · rumo@secardiologia.es
Recruiting
Complexo Hospitalario Universitario A Coruña
A Coruña, Spain
- Xacobe Flores Ríos, MD · Contact · xacobe.flores.rios@sergas.es
Recruiting
Complejo Hospitalario Universtario de Albacete
Albacete, Spain
- Jesús Jiménez-Mazuecos, MD · Contact · JesusM.Jimenez@uclm.es
Recruiting
Hospital General de Alicante
Alicante, Spain
- José Valencia, MD · Contact · jvalenciam@hotmail.com
Recruiting
Hospital Universitario Infanta Cristina
Badajoz, 06080, Spain
- Jose Ramón López Minguez, MD · Contact · lopez-minguez@hotmail.com
Recruiting
Hospital Germans Trias i Pujol
Badalona, Spain
- Omar Abdul Jawad Altisent, MD · Contact · uzarasl@yahoo.es
Recruiting
Hospital de la Santa Creu i Sant Pau
Barcelona, 08025, Spain
- Marcelo Jiménez Kockar, MD · Contact · mjimenezKo@santpau.cat
Recruiting
Hospital Clinic de Barcelona
Barcelona, 08036, Spain
- Monica Masotti, MD · Contact · MASOTTI@clinic.cat
Recruiting
Hospital del Mar
Barcelona, Spain
- Beatriz Vaquerizo, MD · Contact · beavaquerizo@yahoo.es
Recruiting
Hospital Puerta del Mar
Cadiz, Spain
- Alejandro Gutiérrez, MD · Contact · aleklos@hotmail.com
Recruiting
Hospital General Universitario de Ciudad Real
Ciudad Real, Spain
- Fernando Lozano Ruiz-Poveda, MD · Contact · drlozano68@gmail.com
Recruiting
Hospital Universitario Reina Sofía
Córdoba, Spain
- Soledad Ojeda Pineda, MD · Contact · soledad.ojeda18@gmail.com
Recruiting
Hospital de Cabueñes
Gijón, Spain
- Íñigo Lozano Martínez-Luengas, MD · Contact · inigo.lozano@gmail.com
Recruiting
Hospital Universitario Virgen de las Nieves
Granada, 18014, Spain
- Rafael Melgares, MD · Contact · rafael.melgares.sspa@juntadeandalucia.es
Recruiting
Hospital Juan Ramón Jiménez
Huelva, Spain
- Santiago Camacho-Freire, MD · Contact · navallana@hotmail.com
Recruiting
Complejo Asistencial Universitario de León
León, 24071, Spain
- Armando Pérez de Prado, MD · Contact · aperez@secardiologia.es
Recruiting
Hospital Universitario de La Princesa
Madrid, 28006, Spain
- Fernando Alfonso Manterola, MD, PhD · Contact · falf@hotmail.com
- Marcos Garcia Guimaraes, MD · Contact · registronacionaldce@gmail.com
Recruiting
Hospital Ramón y Cajal
Madrid, 28034, Spain
- Rosana Hernández, MD · Contact · rhernandez_antolin@hotmail.com
Recruiting
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
- Maite Velazquez, MD · Contact · maitevel05@gmail.com
Recruiting
Hospital Universitario La Paz
Madrid, 28046, Spain
- Raúl Moreno, MD · Contact · raulmorenog@hotmail.com
Recruiting
Hospital Clínico San Carlos
Madrid, Spain
- Fernando Macaya Ten, MD · Contact · fernando.macaya.ten@gmail.com
Recruiting
Hospital General Universitario Gregorio Marañon
Madrid, Spain
- Ricardo Sanz Ruiz, MD · Contact · rsanzruiz@hotmail.com
Recruiting
Hospital Universitario de Torrejon
Madrid, Spain
- Eduardo Alegría Barrero, MD · Contact · eduar.alegria@gmail.com
Recruiting
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
- Felipe Navarro del Amo, MD · Contact · fnavarroa@fjd.es
Recruiting
Hospital Universitario Virgen de la Victoria
Málaga, Spain
- Víctor Becerra, MD · Contact · vmbecerram@gmail.com
Recruiting
Hospital de Salamanca
Salamanca, Spain
- Ignacio Cruz Gonzalez, MD · Contact · cruzgonzalez.ignacio@gmail.com
Recruiting
Hospital Universitario Virgen Macarena
Sevilla, Spain
- Rafael Ruiz Salmeron, MD · Contact · rjruizsalmeron@yahoo.es
Recruiting
Complejo Hospitalario de Toledo
Toledo, 45004, Spain
- José Moreu, MD · Contact · jmoreu@sescam.jccm.es
Recruiting
Hospital Clínico Universitario de Valencia
Valencia, Spain
- Juan Sanchís, MD · Contact · sanchis_juafor@gva.es
Recruiting
Hospital Universitario y Politécnico La Fe
Valencia, Spain
- José Luis Díez Gil, MD · Contact · diez_jlu@gva.es
Recruiting
Hospital Universitario Miguel Servet
Zaragoza, Spain
- Georgina Fuertes Ferre, MD · Contact · georginaff@hotmail.com
Recruiting

References and documents

Publications

Alfonso F, Sanz-Ruiz R, Sabate M, Macaya F, Roura G, Jimenez-Kockar M, Nogales JM, Velazquez M, Veiga G, Camacho-Freire S, Moreu J, Pelaez JAF, Perez-Espejo P, Amat-Santos IJ, Diez-Villanueva P, Bastante T, Del Val D, Rivero F, Garcia-Guimaraes M. Clinical Implications of the "Broken Line" Angiographic Pattern in Patients With Spontaneous Coronary Artery Dissection. Am J Cardiol. 2022 Dec 15;185:1-9. doi: 10.1016/j.amjcard.2022.09.017. Epub 2022 Oct 13. PubMed 36244863 ↗
Garcia-Guimaraes M, Masotti M, Sanz-Ruiz R, Macaya F, Roura G, Nogales JM, Tizon-Marcos H, Velazquez-Martin M, Veiga G, Flores-Rios X, Abdul-Jawad Altisent O, Jimenez-Kockar M, Camacho-Freire S, Moreu J, Ojeda S, Santos-Martinez S, Sanz-Garcia A, Del Val D, Bastante T, Alfonso F; Spanish Registry on SCAD investigators. Clinical outcomes in spontaneous coronary artery dissection. Heart. 2022 Sep 12;108(19):1530-1538. doi: 10.1136/heartjnl-2022-320830. PubMed 35410894 ↗
Alfonso F, Garcia-Guimaraes M, Alvarado T, Sanz-Ruiz R, Roura G, Amat-Santos IJ, Abdul-Jawad Altisent O, Tizon-Marcos H, Flores-Rios X, Masotti M, Perez-de Prado A, Ferre GF, Ruiz-Poveda FL, Valero E, Portero-Portaz JJ, Diez-Villanueva P, Salamanca J, Bastante T, Rivero F. Clinical implications of arterial hypertension in patients with spontaneous coronary artery dissection. Coron Artery Dis. 2022 Mar 1;33(2):75-80. doi: 10.1097/MCA.0000000000001043. PubMed 33878074 ↗
Diez-Villanueva P, Garcia-Guimaraes M, Sanz-Ruiz R, Roura G, Macaya F, Barahona Alvarado JC, Tizon-Marcos H, Flores-Rios X, Masotti M, Lezcano-Pertejo C, Cortes C, Fuertes-Ferre G, Becerra-Munoz VM, Lozano Ruiz-Poveda F, Valero E, Portero-Portaz JJ, Vera A, Salamanca J, Alfonso F. Spontaneous coronary artery dissection in old patients: clinical features, angiographic findings, management and outcome. Eur Heart J Acute Cardiovasc Care. 2021 Oct 27;10(8):926-932. doi: 10.1093/ehjacc/zuaa029. PubMed 33620451 ↗
Diez-Villanueva P, Garcia-Guimaraes MM, Macaya F, Masotti M, Nogales JM, Jimenez-Kockar M, Velazquez M, Lozano I, Moreu J, Avanzas P, Salamanca J, Alfonso F. Spontaneous Coronary Artery Dissection and Menopause. Am J Cardiol. 2021 Jun 1;148:53-59. doi: 10.1016/j.amjcard.2021.02.007. Epub 2021 Feb 20. PubMed 33617813 ↗
Garcia-Guimaraes M, Bastante T, Macaya F, Roura G, Sanz R, Barahona Alvarado JC, Tizon H, Flores-Rios X, Moreu J, Ojeda S, Nogales JM, Veiga G, Masotti M, Camacho-Freire SJ, Jimenez-Valero S, Jimenez-Kockar M, Lozano I, Gonzalez-Ferreiro R, Velazquez M, Avanzas P, Rivero F, Alfonso F. Spontaneous coronary artery dissection in Spain: clinical and angiographic characteristics, management, and in-hospital events. Rev Esp Cardiol (Engl Ed). 2021 Jan;74(1):15-23. doi: 10.1016/j.rec.2020.04.002. Epub 2020 May 14. English, Spanish. PubMed 32418854 ↗

Individual participant data

Plan to share: Undecided

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Aug 2, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT03607981
Lead sponsor: Spanish Society of Cardiology
Responsible party: Fernando Alfonso (Head of Cardiology Department, Hospital Universitario de La Princesa, Madrid, Spain, Spanish Society of Cardiology) — Principal investigator
First posted: Jul 31, 2018
Start date: Jan 1, 2015
Primary completion: Jan 1, 2019 (estimated)
Completion: Jan 1, 2020 (estimated)
Last update: Aug 2, 2018

Study contacts

Marcos Garcia-Guimaraes, MD

Contact

registronacionaldce@gmail.com

0034666681608

Oversight

Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Aortic Dissection→

Other studies from this sponsor

Spanish Society of Cardiology

Start the discussion