An observational study in Preeclampsia and Periodontal Disease, sponsored by Recep Tayyip Erdogan University Training and Research Hospital. Status unknown at 5 sites in 2 countries. Open to female participants aged 21 Years to 34 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-27.
Sponsored by Recep Tayyip Erdogan University Training and Research Hospital · Observational
The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preeclampsia.
The secondary objective of the study is to analyze the relationship between preeclampsia and periodontal infection, using clinical, biochemical and microbiological methods.
Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established.
Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preeclampsia. It is believed that the results will set light to the etiology of preeclampsia and will help to develop strategies to prevent the disease.
830 studies on the registry are indexed under Periodontal Diseases; 188 are open to participants now.
This study's planned enrollment of 100 is close to the median of 100 across 291 observational studies indexed under Periodontal Diseases.
Browse Periodontal Diseases studies →Recep Tayyip Erdogan University Training and Research Hospital is the lead sponsor of 85 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study is planned to be a case-control study. Workgroup consists of 50 patients which diagnosed with preeclampsia between the age of 18 and 40. Control group consists of healthy females over 37. weeks of pregnant with no history of preeclampsia.
Exclusion Criteria:
18-40 aged diagnosed with preeclampsia
Diagnostic Test: preeclampsia · Diagnostic Test: control
18- 40 aged healthy females over 37. weeks of pregnant with no history of preeclampsia
Diagnostic Test: preeclampsia · Diagnostic Test: control
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
Also known as: blood sample, urine test
liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine
Also known as: blood sample, urine test
prostaglandin E2
prostaglandin E2 levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml
Time frame: 1 Day
TNF-Alpha (Tumor necrosis factor -Alpha)
TNF-Alpha levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml
Time frame: 1 day
IL-1beta (Interleukin 1 beta)
IL-1beta levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml
Time frame: 1 day
Porphyromonas gingivalis
Presence of Porphyromonas gingivalis will be checked by rPCR method. Score 1: Present Score 2: None Tannerella Forsythia (+,-)
Time frame: 1 Day
Tannerella Forsythia
Presence of Tannerella Forsythia will be checked by rPCR method. Score:1 Present. Score 2: None
Time frame: 1 Day
Plan to share: No — Data will be available within 6 months of study completion
This study is status unknown, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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Recep Tayyip Erdogan University Training and Research Hospital