An observational study in Depression Disorder and Healthy, sponsored by Beijing Normal University. Completed. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-06-11.
Sponsored by Beijing Normal University · Observational
To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. The disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. Negative self-bias was found to serve as the core cognitive mechanism of depression disorder. However, there was no evidence to show the reason lead to negative bias. In the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.
To test investigators' hypothesis, investigators adopted the self-referential task and fMRI to investigate the neural representation of self in depression patients, and compared with healthy control.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 23 is below the median of 160 across 1,084 observational studies indexed under Depression.
Browse Depression studies →Beijing Normal University is the lead sponsor of 30 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Individuals diagnosed with depression and healthy control
Exclusion Criteria:
Neural representation of self
We adopted the self referential task. In the task, participants were asked to judge whether a given word was appropriate to describe oneself (self-judgement condition), a celebrity (other-judgement condition) by pressing one of the two buttons with the index or middle finger. For judgments of each target person (i.e, self and celebrity), there were 3 categories of words describing the mental (personality traits, such as hard-working, friendly), physical (physical attributes, such as black hair, big eyes) and social (social roles, such as student, American) dimension of person knowledge. The fMRI task contained 6 runs, with 4.6 minutes per run. This paradigm and task allowed us to investigated the neural representation of self by comparing the BOLD activity under self-judgement condition with BOLD activity under other-judgement condition.
Time frame: through study completion, an average of 2 year
No study locations are listed for this record.
Plan to share: No
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This study is completed, as verified in Feb 2018. You cannot join it, but the record below documents what was studied.
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Beijing Normal University