An interventional study of Sensory testing of lower urinary tract. and Sensory testing of lower rectal tract in Chronic Pelvic Pain and Chronic Perineal Pain, sponsored by Nantes University Hospital. Terminated at 2 sites in France. Open to female participants aged 25 Years and older. Per ClinicalTrials.gov, last updated 2022-04-05.
Sponsored by Nantes University Hospital · Not applicable, Interventional, and Basic science
The purpose of this study is to assess and validate the clinical criteria of sensitization ("Convergences PP criteria") selected by the expert consensus with neurophysiological sensory testing.
Some patient with chronic pelvic or perineal pain, present complex manifestations, comprising pain and dysfunction which does not involved a single organ. The gap between clinical symptoms and pathological signs is a constant feature of these pain syndromes. A possible explanation for these pain syndromes is central sensitization. This sensitization is defined by decrease nociceptive thresholds, a more intense and more prolonged response to nociceptive stimulus, and spatial extension of the painful area. It has been defined by international expert consensus in 2016 a clinical evaluation tool with 10 criteria for sensitization diagnosis: Convergences PP criteria. The aim of this study is to objectivize lower threshold, spatial and temporal diffusion of pain in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) compared to women without sensitization (Convergences PP criteria \< 5). A sensory testing of lower urinary tract, lower rectal tract, vulva and pelvic muscles will be achieved.
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Exclusion Criteria:
Patients with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5)
Other: Sensory testing of lower urinary tract. · Other: Sensory testing of lower rectal tract · Other: Sensory testing of vulva muscles · Other: Sensory testing of pelvic muscles
Patients with chronic pelvic or perineal pain without sensitization (Convergences PP criteria \< 5)
Other: Sensory testing of lower urinary tract. · Other: Sensory testing of lower rectal tract · Other: Sensory testing of vulva muscles · Other: Sensory testing of pelvic muscles
Non invasive lower urinary tract sensitivity testing: provoked diuresis with sonographic estimates of sensory thresholds.
Lower digestive tract sensitivity testing: rectal electronic barostat with ascending pressure (phasic distension).
Vulvar sensitivity testing: pressure pain threshold evaluated using vulvagesiometer.
Myofascial sensitivity testing: piriformis, levator ani and obturator internus muscles pressure pain threshold evaluated using intra-vaginal algometer.
Comparison of pelvic pain threshold
Comparison of pelvic pain threshold obtained by 4 neurophysiological testing, between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) and without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
Identification of temporal distribution of pain
Identification of temporal distribution of pain in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) compared to women without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
Identification of lower pain perception thresholds
Identification of lower pain perception thresholds in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) compared to women without sensitization (Convergences PP criteria \< 5) for each of the 4 neurophysiological testing.
Time frame: 1 month after inclusion in the study
Comparison of state anxiety
Comparison of state anxiety between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) and without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
Comparison of depression
Comparison of depression between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) and without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
Comparison of catastrophizing
Comparison of catastrophizing between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) and without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
Comparison of quality of life
Comparison of quality of life between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria \> 5) and without sensitization (Convergences PP criteria \< 5).
Time frame: 1 month after inclusion in the study
This study is terminated, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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