ClinicalTrials.gg
Status unknownNCT03521947Updated May 11, 2018

Management of Childhood Pancytopenia

An observational study in Pancytopenia, sponsored by Assiut University. Status unknown. Open to participants aged 4 Weeks to 18 Years. Per ClinicalTrials.gov, last updated 2018-05-11.

Sponsored by Assiut University · Observational

The sponsor has not verified this record recently (last verified May 2018), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
25
Ages
4 Weeks to 18 Years
Sex
All
01

Study summary

Pancytopenia is an important hematologic Problem.it is a decrease in all three cellular elements of peripheral blood leading to aneamia, leucopenia and thrombocytopenia.

Read the detailed description

Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dysnea, brusing and increased tendency to infections.

The incidence of various disorders causing pancytopenia varies according to Geographical distribution and genetic mutations. It can result from :

  • Failure of production of hematopoietic progenitors in bone marrow as in aplastic aneamia.
  • Bone marrow infiltration by malignant cells as in acute leukemia.
  • Antibodies mediated bone marrow suppression as in systemic lupus.
  • Ineffective hematopoiesis and dysplasia as in nutrition deficiency.
  • Peripheral sequestration of blood cells in over active reticuloendothelial system as in hypersplenism.

Pancytopenia is not a disease entity but a triad of findings that may result from primary or secondary bone marrow involvement.

Bone marrow aspiration and biopsy evaluation along with clinical correlation are important to evaluate the causes of pancytopenia and plan further investigations and treatment.

Pancytopenia can result from damage to bone marrow evidanced by low reticulocyte count, or increased destruction of the peripheral blood with increased reticulocyte count.

Bone marrow examination is a simple and safe invasive procedure for evaluating the causes of pancytopenia.

The hypoplastic marrow which occurs in 2% of pediatrics acute lymphoblastic leukemia may be misdiagnosed as aplastic aneamia.

Studies done have shown leukemia to be the second most common cause of pancytopenia in pediatrics, marginally behind aplastic aneamia.

02

Conditions studied

  • Pancytopenia

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Keywords

  • MCP
03

In context

Pancytopenia

22 studies on the registry are indexed under Pancytopenia; 4 are open to participants now.

Browse Pancytopenia studies →

Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
4 Weeks to 18 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

Childrens and adolescents from age one month up to 18 years old suffering from pancytopenia.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All childrens and adolescents suffering from pancytopenia attending heamatology unit of pediatric department Assiut University Hospital will be included.

Exclusion criteria

Exclusion Criteria:

  • childrens and adolescents suffering from pancytopenia due to .
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
25 participants (estimated)
Patient registry
No

Groups and cohorts

  • One group of children below 18 years old

    Diagnostic Test: Complete blood picture

Interventions

  • Diagnostic testComplete blood picture

    Iaboratory investigation

06

What researchers measure

Primary outcomes

  1. Availability

    Bone marrow examination for all cases \[evaluate the causes of pancytopenia and plan further investigations and treatment.\]

    Time frame: One year

Secondary outcomes

  1. Modification

    Guidelines for management of pancytopenia modified or not? \[Strategy of blood elements transfusion in treatment\]

    Time frame: One year

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Hayat,A.S, Khan,A.H,GH and Shaikh, N . (2014). Pancytopenia :study for clinical features and Etiological pattern at a tertiary care settings in Abbottabad.The professional medical journal, 21,060-065.
  • Raja S, Suman FR, Scott JX, Latha MS, Rajenderan A, Ethican A. Pancytopenia - (?) An obstacle in the diagnosis and outcome of pediatric acute lymphoblastic leukemia. South Asian J Cancer. 2015 Apr-Jun;4(2):68-71. doi: 10.4103/2278-330X.155648. PubMed 25992344 ↗
  • Desalphine M, Bagga PK, Gupta PK, Kataria AS. To evaluate the role of bone marrow aspiration and bone marrow biopsy in pancytopenia. J Clin Diagn Res. 2014 Nov;8(11):FC11-5. doi: 10.7860/JCDR/2014/9042.5169. Epub 2014 Nov 20. PubMed 25584228 ↗
  • Al-Khalisi, K.A,Al-zubaidy, A. S and Rhaima. M. 2011.Pancytopenia adult patients atBaghdad Teatching Hospital. The Iraqi postgraduate medical journals, 10,441-448

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 11, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03521947
Lead sponsor
Assiut University
Responsible party
Asmaa Otify (Resident doctor of pediatrics, Assiut University) — Principal investigator
First posted
May 11, 2018
Start date
Jun 1, 2018 (estimated)
Primary completion
Jun 1, 2019 (estimated)
Completion
Dec 1, 2019 (estimated)
Last update
May 11, 2018

Study contacts

Ahmed Gadelrab Askr, Professor
Contact
ahmed.mohamed35@med.au.edu.eg
01114064050

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2018. You cannot join it, but the record below documents what was studied.

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