An observational study in Hyperuricemia, Metabolic Syndrome and Left Ventricular Diastolic Dysfunction, sponsored by National Defense Medical Center, Taiwan. Terminated at 1 site in Taiwan. Open to participants aged 20 Years to 75 Years. Per ClinicalTrials.gov, last updated 2018-04-12.
Sponsored by National Defense Medical Center, Taiwan · Observational
Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained unclear. The aim of the present study focuses on the association among hyperuricemia, diastolic dysfunction and inflammatory biomarkers in apparently healthy individuals with metabolic syndrome
Apparently healthy individuals with metabolic syndrome were prospectively and consecutively enrolled since August 2017. Blood samples were obtained after participants are fasting for at least 12 hours, including serum uric acid, high-sensitivity C-reactive protein, high-sensitivity interleukin-6, tumor necrotizing factor alpha, fasting glucose, glycosylated hemoglobin, insulin, lipid profile, creatinine, alanine aminotransferase, sodium, potassium, and calcium. All echocardiographic parameters were measured in accordance with the American Society of Echocardiography guidelines.
240 studies on the registry are indexed under Hyperuricemia; 44 are open to participants now.
This study's enrollment of 67 is below the median of 183 across 40 observational studies indexed under Hyperuricemia.
Browse Hyperuricemia studies →National Defense Medical Center, Taiwan is the lead sponsor of 64 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Apparently healthy individuals with metabolic syndrome
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Serum uric of 7mg/dl or less in men or 6mg/dl or less in women
Diagnostic Test: hyperuricemia
Serum uric of 7mg/dl or more in men or 6mg/dl or more in women
Diagnostic Test: hyperuricemia
serum uric acid of 7mg/dl or more in men or 6mg/dl or more in women
Left ventricle diastolic dysfunction with elevated left atrial pressure
The contemporary definition of left ventricular diastolic dysfunction with elevated left atrial pressure is mainly \>50% positive of the following criteria: (1) average E/e' ≥14 (2) left atrial volume index \>34 ml/m2 (3) tricuspid regurgitation velocity \>2.8 m/s
Time frame: 1 day
high-sensitivity C-reactive protein
determined by Latex enhanced immunoturbidimetric，ADVIA 1800，ADVIA Chemistry XPT，Dimension RXL，SIEMENS，AU 640，Beckman Coulter
Time frame: 1 week
high-sensitivity interleukin-6
determined by elisa enzyme-linked immunosorbent assay, R \& D system
Time frame: 1 month
tumor necrotizing factor alpha
determined by elisa enzyme-linked immunosorbent assay
Time frame: 1 month
Plan to share: No
No publications or documents are linked to this record.
Ran from Aug 2017 to primary completion in Dec 2017, 4 months.
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This study is terminated, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.
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National Defense Medical Center, Taiwan