A Phase 4 interventional study of bupivacaine and dexamethasone and bupivacaine and lidocaine in Total Knee Arthroplasty, Adductor Canal Block and Sciatic Nerve Block, sponsored by Mahidol University. Status unknown at 1 site in Thailand. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2018-04-03.
Sponsored by Mahidol University · Phase 4, Interventional, and Treatment
This study evaluate the efficacy of adding popliteal sciatic nerve block with low concentration bupivacaine and dexamethasone to abductor canal block for total knee arthroplasty in patient with NSAIDs prescribing precaution. Half of participants will receive popliteal sciatic nerve block, abductor canal block and periarticular injection, while the other half will receive a sham block, abductor canal block and periarticular injection.
After informed and consent, all patients will be devided into two groups, Sciatic group (group S) and Controlled group (group C). All patients will receive adductor canal block, then patients in group S will receive Sciatic nerve block with low concentration bupivacaine and dexamethasone while partients in group C will receive sham block. All patient will receive spinal anesthesia and intraoperative periarticular injection.
Postoperative pain score, muscle strength, total morphine consumption and adverse events will be record in case record form.
Mahidol University is the lead sponsor of 747 studies on the registry; 119 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
GFR and eGFR (kidney filtering)
GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².
Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
adductor canal block with sham block
Drug: bupivacaine and lidocaine · Device: Ultrasound
adductor canal block with popliteal sciatic nerve block
Drug: bupivacaine and dexamethasone · Device: Ultrasound
Drug pages: Bupivacaine · Dexamethasone
adductor canal block with 0.33% bupivacaine 15 ml with ultrasound guided popliteal sciatic block with 0.125% bupivacaine 20 ml and dexamethasone 5 mg
Also known as: bupivacaine
adductor canal block with 0.33% bupivacaine 15 ml with ultrasound at popliteal sciatic area and subcutaneous infiltration popliteal area with 2% lidocaine 1 ml
ultrasound
postoperative pain score at rest
postoperative pain score at rest at 24 hour
Time frame: postoperative 24 hours
postoperative pain score at anterior and posterior site of knee
postoperative pain score at anterior and posterior site of knee at 24 hour
Time frame: postoperative 24 hours
postoperative pain score on 45 degree knee flexion and physical therapy
postoperative pain score on 45 degree knee flexion and physical therapy
Time frame: postoperative 24 hours
level of tibialis anterior muscle weakness
level of tibialis anterior muscle weakness in 24 hour
Time frame: postoperative 24 hours
adverse events
perioperative adverse events such as LAST, hypotension, nausea and vomitting
Time frame: postoperative 24 hours
total morphine consumption in postoperative 24 hours
total morphine consumption in postoperative 24 hours
Time frame: postoperative 24 hours
patient satisfaction
patient satisfaction score
Time frame: postoperative 24 hours
length of hospital stay
length of hospital stay
Time frame: 7 days
Plan to share: No
Start is estimated for Apr 2018; primary completion for Feb 2019, 10 months later.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drugs tested here: Bupivacaine · Dexamethasone