ClinicalTrials.gg
CompletedNCT03481257Updated Mar 29, 2018

Comparison Between Ticagrelor Versus Very Low Dose Rivaroxaban With Clopidogrel

An observational study in Acute Coronary Syndrome, Acute Myocardial Infarction and Unstable Angina, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-03-29.

Sponsored by Seoul National University Hospital · Observational

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Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
56
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 11 studies in Acute Coronary Syndrome by Seoul National University Hospital — none open to participants now, none under way, none of them phase 3. Acute Coronary Syndrome · Seoul National University Hospital.

Started
2017
the only one that year
Observational
9 of 11
none open now
Registered
9th of 11
by date

Among the 11 studies in Acute Coronary Syndrome by Seoul National University Hospital, this one is the only one that started in 2017, is one of 9 observational ones, and was the 9th registered.

Acute Coronary Syndrome

1,489 studies on the registry are indexed under Acute Coronary Syndrome; 271 are open to participants now.

Browse Acute Coronary Syndrome studies →

Open to participants now

None of the 11 studies in Acute Coronary Syndrome by Seoul National University Hospital is open now. The open studies under Acute Coronary Syndrome, anywhere →

Where they have run

Who these studies take

Of the 195 Acute Coronary Syndrome studies recruiting now, 144 (74%) set no upper age limit and 19 (10%) stop at 75 or younger; 14 take children under 18; 15 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

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Download CSVNarrow it in search →With an account: the 11 studies in Acute Coronary Syndrome by Seoul National University Hospital as a file.
02

Study summary

A total of 50 participants diagnosed with ACS (group A ticagrelor 180mg/d, n=25), group B (clopidogrel 75mg + rivaroxaban 5mg/ d, n=25)) were consecutively enrolled and treated with study drugs on top of aspirin (100mg/d) for 1 month. VerifyNow® and Global thrombosis test were performed at day 2 and 1 month after administration of study drugs. The investigators compared aspirin reaction unit (ARU) and P2Y12 reaction unit (PRU), occlusion time (OT) which reflects shear stress-induced thrombotic activity, and lysis time (LT) which showed endogenous lytic activity between the two strategies at both time points.

03

Conditions studied

  • Acute Coronary Syndrome
  • Acute Myocardial Infarction
  • Unstable Angina
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Fifty-six patients from 452 patients who underwent percutaneous coronary intervention (PCI) due to ACS in Seoul National University Bundang Hospital. ( April 2017\~ January 2018)

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who were diagnosed with acute coronary syndrome and underwent percutaneous coronary intervention

Exclusion criteria

Exclusion Criteria:

  • Patients administered with glycoprotein IIb/IIIa inhibitiors
  • Patients with atrial fibrillation
  • Patients with high risk of bleeding at the physician's discretion
  • Patients with renal impairment (estimated \<30ml/min)
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

GFR and eGFR (kidney filtering)

GFR (glomerular filtration rate) is how much blood the kidneys filter each minute. It is usually estimated from a blood test — eGFR, by formulas such as CKD-EPI or MDRD — and some studies ask for it to be measured directly instead. Usually given in mL/min/1.73 m².

Check the method, the units and the minimum the study states. A value of 90 or above is in the normal-or-high range, but kidney damage can show in other tests too.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
56 participants (actual)
Patient registry
No

Groups and cohorts

  • Ticagrelor

    ACS patients treated with aspirin (100mg/d) and ticagrelor (90mg bid)

  • Clopidogrel + very low dose rivaroxaban

    ACS patients treated with aspirin (100mg/d), clopidogrel(75mg/d) and very low dose rivaroxaban (2.5mg bid)

06

What researchers measure

Primary outcomes

  1. Occlusion time

    Global thrombosis test

    Time frame: 1 month

Secondary outcomes

  1. Lysis time

    Global thrombosis test

    Time frame: 1 month

  2. Occlusion time

    Global thrombosis test

    Time frame: Day 2

  3. Lysis time

    Global thrombosis test

    Time frame: Day 2

  4. P2Y12 reaction unit

    VerifyNow test

    Time frame: Day 2 and 1 month

  5. Aspirin reaction unit

    VerifyNow test

    Time frame: Day 2 and 1 month

Other outcomes

  1. major adverse cardiovascular outcome

    composites of cardiac death, myocardial infarction and target lesion revascularization

    Time frame: 1 month

  2. BARC bleeding

    ARC definition

    Time frame: 1 month

07

Study locations

1 site
  • Seoul National University Bundang Hospital
    Seongnam, Gyeonggi-do 463707, Korea, Republic of
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Apr 2017 to primary completion in Jan 2018, 8 months.

Of 243 non-industry observational studies under Acute Coronary Syndrome, half reached primary completion within 36 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 71. This study's 8 months is below that.

Counting every sponsor, half of 277 studies reached it within 35 months; a quarter within 18 and three quarters within 68.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 21, 2018
First posted
Mar 29, 2018
StartActual
Apr 12, 2017
Primary completionActual
Jan 4, 2018
CompletionActual
Feb 4, 2018
Last update
Mar 29, 2018
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Mar 29, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03481257
Responsible party
Jung-Won Suh (Principal Investigator, Seoul National University Hospital) — Principal investigator
First posted
Mar 29, 2018
Start date
Apr 12, 2017
Primary completion
Jan 4, 2018
Completion
Feb 4, 2018
Last update
Mar 29, 2018

Study contacts

Jung-Won Suh
principal investigator · Seoul National University Bundang Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.

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Discussion

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