An interventional study of saliva in Cardiac Disease and Dental Caries, sponsored by Istanbul University. Completed. Open to participants aged 3 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-03-08.
Sponsored by Istanbul University · Not applicable, Interventional, and Diagnostic
The purpose of this study was to evaluate whether there are relationships between the salivary oxidative stress status of children with CHD directly dental caries including gender, age, salivary flow rate, salivary pH, salivary buffering capacity and drug intake such as angiotensin-converting enzyme (ACE) inhibitors. If such relationships exist, they might be employed to patient caries -prevention treatment.
Using heart failure medications may cause low salivary pH and buffering capacity.As improved oral health is a priority for cardiac patients, it is necessary that they attend dental clinics for regular follow up.
This cross sectional study was carried out with 42 CHD and 42 healthy children who applied to Istanbul University, Faculty of Dentistry, Department of Pedodontics. Gender, age, general health and medications, and caries scores (dfs/DMFS) were recorded. Unstimulated saliva was collected from the participants and were assessed for the salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.
Exclusion Criteria:
42 patients
Other: saliva
42 children
Other: saliva
salivary secretion rate, salivary buffering capacity, pH, protein levels, superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), the thiobarbituric acid reactive substances (TBARS), protein carbonyl, protein thiols, total sialic acid.
salivary secretion rate
salivary secretion rate
Time frame: 2 hour
salivary buffering capacity
salivary buffering capacity
Time frame: 2 hour
pH
pH
Time frame: 2 hour
protein levels of saliva
protein levels
Time frame: 2 hour
superoxide dismutase (SOD)
superoxide dismutase (SOD)
Time frame: 2 hour
ferric reducing antioxidant power (FRAP)
ferric reducing antioxidant power (FRAP)
Time frame: 2 hour
the thiobarbituric acid reactive substances (TBARS)
the thiobarbituric acid reactive substances (TBARS)
Time frame: 2 hour
protein carbonyl
protein carbonyl
Time frame: 2 hour
protein thiols
protein thiols
Time frame: 2 hour
total sialic acid
total sialic acid
Time frame: 2 hour
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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Istanbul University