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Active, not recruitingNCT03424668EPIC-NorfolkUpdated Apr 16, 2019

The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

An observational study in Neoplasms, Cardiovascular Diseases and Death, sponsored by University of Cambridge. Active, not recruiting. Open to participants aged 39 Years to 79 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-16.

Sponsored by University of Cambridge · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
25,639
Ages
39 Years to 79 Years
Sex
All
01

Study summary

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Read the detailed description

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

02

Conditions studied

  • Neoplasms
  • Cardiovascular Diseases
  • Death

Keywords

  • nutrition
  • physical activity
  • lifestyle
  • smoking
03

In context

Neoplasms

10,818 studies on the registry are indexed under Neoplasms; 2,324 are open to participants now.

This study's enrollment of 25,639 is above the median of 200 across 2,638 observational studies indexed under Neoplasms.

Browse Neoplasms studies →

Lead sponsor

University of Cambridge is the lead sponsor of 116 studies on the registry; 23 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
39 Years to 79 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Resident in Norfolk, United Kingdom on general practice age sex registers 1993-1997

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Willing to participate
  • On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion criteria

Exclusion Criteria:

  • Not willing to participate in study
  • terminal illness
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
25,639 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Interventions

  • Behavioraldiet

    lifestyle factors

    Also known as: physical activity

06

What researchers measure

Primary outcomes

  1. neoplasms

    cancer incidence

    Time frame: Through 25 years

Secondary outcomes

  1. cardiovascular diseases

    incidence of cardiovascular diseases

    Time frame: through 25 years

  2. death

    total mortality by cause

    Time frame: through 25 years

Other outcomes

  1. fractures

    incident fractures

    Time frame: through 25 years

  2. diabetes mellitus

    incident diabetes

    Time frame: through 25 years

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 Suppl 1:95-103. No abstract available. PubMed 10466767 ↗
  • Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr. 2001 Jun;4(3):847-58. doi: 10.1079/phn2000102. PubMed 11415493 ↗

Individual participant data

Plan to share: Yes — EPIC Norfolk follows Medical Research Council UK good practice for data sharing. Requests for data are submitted to the EPIC Norfolk management committee to assess scientific feasibility and avoid duplication and within the requirements of NHS Digital data protection rules.

Supporting information: Study protocol, Statistical analysis plan, Informed consent form

Time frame: Data are available after collection, cleaning and quality control

Access criteria: Bonafide researchers

Data sharing details ↗ · www.srl.cam.ac.uk

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jan 1992 (actual). Primary completion is estimated for Dec 2040, 587 months after the start.

Of 1,098 non-industry observational studies under Neoplasms, half reached primary completion within 61 months of starting (the median), counting those still running; a quarter within 24 and three quarters within 227. This study's planned 587 months is above that.

Counting every sponsor, half of 1,246 studies reached it within 58 months; a quarter within 24 and three quarters within 210.

Neoplasms covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 25, 2018
First posted
Feb 7, 2018
StartActual
Jan 1, 1992
Primary completionEst.
Dec 31, 2040
CompletionEst.
Dec 31, 2040
Last update
Apr 16, 2019
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 16, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03424668
Collaborators
Medical Research Council, Cancer Research UK
Responsible party
Kay-Tee Khaw (Professor of Clinical Gerontology, University of Cambridge) — Principal investigator
First posted
Feb 7, 2018
Start date
Jan 1, 1992
Primary completion
Dec 31, 2040 (estimated)
Completion
Dec 31, 2040 (estimated)
Last update
Apr 16, 2019

Study contacts

Nicholas Wareham, MBBS
principal investigator · University of Cambridge
Kay-Tee Khaw, MBBChir
principal investigator · University of Cambridge

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.

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