An observational study in Aortic Valve Stenosis, sponsored by University Hospital, Rouen. Active, not recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-12-09.
Sponsored by University Hospital, Rouen · Observational
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population. Although significant progress has been made in understanding the pathophysiological mechanisms underlying the onset and progression of AS, there is no medical treatment to slow or prevent its progression. The only treatment available is Aortic Valve Replacement (AVR) performed by surgery or by catheterization (TAVI).
AS is associated with an increase of post-load which leads the left ventricular myocardium to hypertrophy. Associated with hypertrophy, myocardial fibrosis will gradually develop. Despite interesting data, many unknowns persist and remain to be identified.
The aim of the study is to characterize prospectively the left ventricular remodeling and assess its changes after AVR and within 1 year in 500 patients using clinical, biological, echocardiographic and MRI parameters.
Patients with at least moderate aortic stenosis and in whom an intervention is programmed or indicated
Exclusion Criteria:
Occurrence of clinical events according to left ventricular remodeling
Echocardiography and MRI
Time frame: Year 1
Occurrence of clinical events according to left ventricular remodeling
Echocardiography and MRI
Time frame: Year 2
Occurrence of clinical events according to left ventricular remodeling
Echocardiography and MRI
Time frame: Year 3
Occurrence of clinical events according to left ventricular remodeling
Echocardiography and MRI
Time frame: Year 4
Evolution of left ventricular remodeling after aortic valvular replacement
Echocardiography and MRI
Time frame: Year 1
Prognostic value of persistence and type of left ventricular remodeling
Echocardiography and MRI Occurence of clinical events
Time frame: Year 1
Prognostic value of fibrosis
Echocardiography and MRI Occurence of clinical events
Time frame: Year 1
Prognostic value of biomarkers
Time frame: Year 1
This study is active, not recruiting, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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University Hospital, Rouen