An interventional study of Daily interruption of midazolam in Respiratory Failure, Midazolam Overdose and Chronic Obstructive Pulmonary Disease, sponsored by Assiut University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2018-01-23.
Sponsored by Assiut University · Not applicable, Interventional, and Treatment
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.
there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .
Exclusion Criteria:
Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion
Drug: Daily interruption of midazolam
No sedation will be given after initiation of mechanical ventilation
daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done
Also known as: sedation interruption
duration of mechanical ventilation
number of days of mechanical ventilation
Time frame: first 30 days
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Assiut University