An interventional study of High flow oxygen and Low flow oxygen in Stroke, sponsored by Chulalongkorn University. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-01-18.
Sponsored by Chulalongkorn University · Not applicable, Interventional, and Treatment
Hypoxemia is common in acute ischemic stroke and associated with neurological deterioration and mortality. However, the benefit of oxygen therapy is controversial. Severity of stroke may affect the benefit of oxygen supplementation. Abnormal breathing patterns are commonly found among stroke patients and may increase the risk of hypoxemia. High flow nasal cannula (HFNC) has several advantages from controllable fraction of inspired oxygen (FiO2), reduction of nasopharyngeal resistance and positive end expiratory pressure effect. In this study, we aimed to assess the therapeutic effect of HFNC on oxygen desaturation index (ODI) and neurological outcomes in stroke patients with moderate and severe severities, compared with no and low flow oxygen supplementation.
Exclusion Criteria:
No oxygen supplementation given
Oxygen cannula with a flow rate of 2 liter/minute
Device: Low flow oxygen
Heated humidified high flow oxygen cannula (Optiflow; temperature of 34°C and fractional inspired oxygen of 0.24) with a flow rate of 20 liter/minute
Device: High flow oxygen
Heated humidified high flow oxygen cannula (Optiflow; temperature of 34°C and fractional inspired oxygen of 0.24) with a flow rate of 20 liter/minute
Oxygen cannula with a flow rate of 2 liter/minute
Oxygen desaturation index
The number of times per hour that the oxygen saturation measured by pulse oximetry drop from baseline more than 4% for at least 10 seconds
Time frame: In the first 24 hours of study period
Mean oxygen saturation
Time frame: In the first 24 hours of study period
Lowest oxygen saturation
Time frame: In the first 24 hours of study period
The number of subjects with oxygen desaturation
Time frame: In the first 24 hours of study period
Percentages of cumulative time of oxygen desaturation
Time frame: In the first 24 hours of study period
NIHSS changes
The NIHSS at randomization minus the NIHSS at the 7th day of admission
Time frame: at the 7th day of admission or at discharge date
The number of subjects with NIHSS improvement by 4 or more
Time frame: at the 7th day of admission or at discharge date
No study locations are listed for this record.
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Chulalongkorn University