CClinicalTrials.gg
CompletedNCT03394248Updated Apr 14, 2022

The Effects of Subconcussive Events on Cognition

An observational study in Cerebral Injury, sponsored by New York Institute of Technology. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-14.

Sponsored by New York Institute of Technology · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
20
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine early detection of concussion for those at risk of developing symptoms and to be able to detect subconcussive cerebral impairment, and thus gaining a better understanding of the injury patterns for concussions in Men's and Women's Collegiate sports.

Read the detailed description

Description of the Research Subjects will be members of NYIT's Collegiate Athletic Teams. Potential subjects will be informed about the proposed study and asked if the athlete is interested in participating. If the athlete agrees, the key investigator will review the study procedures, what is expected of the subject, and complete the informed consent process. Participation will be completely voluntary and will have no impact on the quality of care the subject will receive. Inclusion and exclusion criteria will then be evaluated by the key investigator to determine if the subject is qualified to participate in this study. Following consent and review of inclusion and exclusion criteria, the subject will be assigned a subject identification number in which is intended to maintain confidentiality of the subject's personal health information. The number will be used for the duration of the study and in all analyses. Once enrolled, the subjects will complete a baseline questionnaire* that will include demographic information and personal history, as well as consent for de-identified information to be shared with a third party, Quadrant Biosciences, for research purposes. The subjects will be evaluated by a series of measurements, ClearEdge, Quadrant Bioscience Salivary Testing, King Devick, and Im PACT, in the preseason, midseason, and postseason, or if they are suspected of a concussion by the athletic trainer or team physician. Visit 1: Baseline Data Collection

  • Assessment Tools
  • Demographic/Baseline questionnaire*
  • ImPACT
  • King-Devick
  • ClearEdge New York Institute of Technology Institutional Review Board Approved From 07/18/20 to 07/17/21
  • Quadrant Bioscience Salivary Testing
  • Quadrant Bioscience Salivary Testing Questionnaire
  • Estimated Time: 1.5 hours Visit 2: Mid-Season Collection
  • Assessment Tools
  • ImPACT
  • King-Devick
  • ClearEdge
  • Quadrant Bioscience Salivary Testing
  • Quadrant Bioscience Salivary Testing Questionnaire
  • Estimated time: 1 hour Visit 3: Post-season Data Collection
  • Assessment Tools
  • ImPACT
  • King-Devick
  • ClearEdge
  • Quadrant Bioscience Salivary Testing
  • Quadrant Bioscience Salivary Testing Questionnaire
  • Estimated time: 1 hr Visit 4: If athlete is suspected to have sustained a concussion by the athletic trainer or team physician, the athlete will come for an additional visit
  • Assessment Tools
  • ImPACT
  • King-Devick
  • ClearEdge
  • Quadrant Bioscience Salivary Testing
  • Quadrant Bioscience Salivary Testing Questionnaire
  • Estimated time: 1 hr
02

Conditions studied

  • Cerebral Injury

Browse trials for

Keywords

  • Subconcussive head injury
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Subjects for this study will be members of the NYIT Athletic Teams.

Inclusion criteria

  • Subject is at least 18 years age and younger than 50 years of age
  • Subject experiences at least 8Gs of force on at least one occasion, as measured by accelerometer

Exclusion criteria

Exclusion Criteria:

  • The subject suffered from any of the following at the time of event leading to a concussion:

    • Loss of consciousness >2 minutes in the field as reported by witness
    • Seizures
    • Intractable vomiting
    • Paralysis
  • The subject has been diagnosed with an underlying neurodegenerative condition that may confound test results (e.g. Parkinson's Disease, Alzheimer's Disease)
  • The subject has a current or previous spinal cord injury
  • The subject is unable to complete assessment tools
  • The subject is pregnant
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
20 participants (actual)
Target follow-up
6 Months
Patient registry
Yes
Biospecimen retention
Samples without dna

Interventions

  • DeviceVector Mouthguard

    The mouthguard will be used by athletes to measure the magnitude and number of impacts throughout one season.

05

What researchers measure

Primary outcomes

  1. Changes in cognition secondary to impact

    A mouthguard with built in sensors to collect data above the predetermined acceleration thresholds. The predetermined threshold for acceleration will be set to 5G in order to collect more data about subconcussive impacts, in addition to concussive impacts

    Time frame: 5 months

Secondary outcomes

  1. ImPACT Testing

    Tool to help detect and assess the severity of concussion in athletes by establishing a baseline of memory and cognitive function

    Time frame: 5 months

  2. King-Devick Test

    Objectively measures visual tracking and saccadic eye movements

    Time frame: 5 months

  3. C3 Logix

    Concussion Assessment application with the ability to track a patient's dynamic vision reflexes and ability to focus on moving objects

    Time frame: 5 months

06

Study locations

1 site
  • New York Institute of Technology
    Old Westbury, New York 11568, United States
07

References and documents

Individual participant data

Plan to share: Undecided — May share with osteopathic medical research students

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT03394248
Lead sponsor
New York Institute of Technology
Responsible party
Matthew Heller (Assistant Professor, Family Medicine, New York Institute of Technology) — Principal investigator
First posted
Jan 9, 2018
Start date
Jan 26, 2018
Primary completion
Jul 3, 2018
Completion
Mar 13, 2020
Last update
Apr 14, 2022

Study contacts

Matthew Heller, D.O
principal investigator · New York Institute of Technology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion