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RecruitingNCT06992271Updated May 28, 2025

Comparing Two Eccentric Protocols on Muscle Damage

An interventional study of Fast Eccentric and Slow Eccentric in Eccentric Hypertrophy and Muscle Damage, sponsored by New York Institute of Technology. Recruiting at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-28.

Sponsored by New York Institute of Technology · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Primary completion was expected by Jun 2025, 1 year 5 months ago, but the record still lists the study as recruiting.
  • Started Mar 2023; still recruiting 3 years 8 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
16
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
All
01

Study summary

The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.

Read the detailed description

Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires.

Session 1 (45 minutes)

  • Complete a demographic questionnaire
  • Self-assess muscle soreness
  • Walk on the treadmill to warm-up
  • Maximal voluntary contraction on the chest press
  • Two sets of eccentric (lowering) bench press at 75% of max

Session 2 (45 minutes)

  • Walk on the treadmill to warm up
  • Maximal voluntary contraction on the chest press
  • Three sets of 10 eccentric contractions at 75% of max
  • Repeat the maximal voluntary contraction on the chest press

Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press

Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

02

Conditions studied

  • Eccentric Hypertrophy
  • Muscle Damage
03

In context

Lead sponsor

New York Institute of Technology is the lead sponsor of 59 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Sixteen young adults (ages 18-35) will be enrolled in this study.
  • In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.

Exclusion criteria

Exclusion Criteria:

  • Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.
  • Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.
  • Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
16 participants (estimated)

Study arms

  • Experimental
    Fast Eccentric

    Participants will perform fast eccentric resistance training

    Behavioral: Fast Eccentric

  • Active comparator
    Slow eccentric

    Participants will perform slow eccentric resistance training

    Behavioral: Slow Eccentric

Interventions

  • BehavioralFast Eccentric

    Resistance training done quickly

  • BehavioralSlow Eccentric

    Resistance training done slowly

06

What researchers measure

Primary outcomes

  1. Muscle soreness 1

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

    Time frame: 1 day

  2. Muscle soreness 2

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

    Time frame: 2 days

  3. Muscle soreness 3

    Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness

    Time frame: 3 days

  4. Maximal Voluntary Isometric Contraction Change

    Change in MVIC will be used to indicated muscle damage.

    Time frame: pre-intervention, immediately after the intervention

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Mar 2023 (actual). Primary completion is estimated for Jun 2025, 26 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 9, 2023
First posted
May 28, 2025
StartActual
Mar 8, 2023
Primary completionEst.
Jun 1, 2025
CompletionEst.
Jun 1, 2025
Last update
May 28, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 28, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06992271
Lead sponsor
New York Institute of Technology
Responsible party
Sponsor
First posted
May 28, 2025
Start date
Mar 8, 2023
Primary completion
Jun 1, 2025 (estimated)
Completion
Jun 1, 2025 (estimated)
Last update
May 28, 2025

Study contacts

Amerigo Rossi, Ed.D
Contact
arossi01@nyit.edu
516 686-3884
Amerigo Rossi, Ed.D
principal investigator · New York Institute of Technology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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