ClinicalTrials.gg
Status unknownNCT03358420Updated Nov 30, 2017

Inflammation and Steatosis: the Role of Alpha-defensin

An observational study in Inflammation and Fatty Liver, sponsored by Hillel Yaffe Medical Center. Status unknown at 1 site in Israel. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2017-11-30.

Primary conditionFatty LiverRegistry: InflammationReclassifiedWhy we changed it
Registry
Inflammation — the first condition term the registry derived for this study.
ClinicalTrials.gg
Fatty Liver
Why
  1. Inflammation is a broad heading, used only when no more specific condition is named.
  2. The study's listed conditions name Fatty Liver.
Confidence
High: the new condition is named in the study's own listed conditions. Of 351 hand-checked studies reclassified this way, 68% were exactly right and 84% in the right disease family; the registry's first term was right for 5% (measured 2026-10-21). How we classify →
Wrong?
Tell us the study's main condition →

Sponsored by Hillel Yaffe Medical Center · Observational

The sponsor has not verified this record recently (last verified Nov 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
50
Ages
15 Years and older
Sex
All
01

Study summary

The aim of this study is to examine the correlation between the severity of non-alcoholic steatohepatitis/non alcoholic fatty liver disease (NASH/NAFLD) in naïve and hepatitis C (HCV) positive patients and the amplitude of alpha-defensin immunohistochemical staining in liver biopsy.

02

Conditions studied

  • Inflammation
  • Fatty Liver

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03

In context

Fatty Liver Reclassified

662 studies on the registry are indexed under Fatty Liver; 184 are open to participants now.

This study's planned enrollment of 50 is below the median of 150 across 206 observational studies indexed under Fatty Liver.

Browse Fatty Liver studies →

Lead sponsor

Hillel Yaffe Medical Center is the lead sponsor of 305 studies on the registry; 10 are open to participants now.

Compared within Fatty Liver, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Inflammation. The counts are of registry records indexed under each term, refreshed daily. How we classify →

04

Who can participate

Ages eligible
15 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients attending our liver unit who underwent a liver biopsy with proven fatty liver disease

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Fatty liver disease patients with liver

Exclusion criteria

Exclusion Criteria:

  • None
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Biopsy and archival tissue

A biopsy takes a small piece of tissue to examine. “Archival tissue” is a sample already taken, for example at diagnosis, and kept by the hospital.

Whether a stored sample will do depends on when it was taken, how much there is and what the study needs. Ask whether the study accepts your stored sample or needs a new biopsy.

05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • Diagnostic testImmunohistochemical staining

    Pathological liver slides to be immunohistochemically stained for alpha-defensin

06

What researchers measure

Primary outcomes

  1. Amplitude of immunohistochemical stain

    The amplitude of each slide will be graded from 1-4

    Time frame: Six months

07

Study locations

1 site
  • Hille Yaffe Medical Center
    Hadera, 38100, Israel
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 30, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03358420
Responsible party
Sponsor
First posted
Nov 30, 2017
Start date
Dec 2017 (estimated)
Primary completion
Jul 2018 (estimated)
Completion
Jul 2018 (estimated)
Last update
Nov 30, 2017

Study contacts

Rami Abu Fanne, MD
Contact
ramia@hadassah.org.il
972-50-3573694
Rami Abu Fanne, MD
study director · Hillel Yaffe Medical Center

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2017. You cannot join it, but the record below documents what was studied.

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