An observational study in Neonatal Early-onset Sepsis, sponsored by Hillel Yaffe Medical Center. Not yet recruiting at 1 site in Israel. Open to participants aged Up to 7 Days. Per ClinicalTrials.gov, last updated 2026-04-07.
Sponsored by Hillel Yaffe Medical Center · Observational
Early neonatal sepsis requires rapid and efficient intervention to prevent morbidity and mortality. Management of such a case includes invasive blood examinations, elongation of maternal and neonatal length of stay, and empiric antibiotic therapy. These actions has major side effects. On 2017, Kaiser-Permanente started using a calculator that weighs the chances for early onset neonatal sepsis, and states the best investigation and follow-up regimn for the specific newborn infant. Eversince, policy of managing neonatal suspected early onset sepsis has chaged globally, including in Israel. Current knowledge regarding the local outcome since the use of the calculatir is scarce.
The goal of the study is to evaluate the change in management of suspected neonatal early onset sepsis, including its economic value, between periods before and after assimilation of the calculator in Hillel Yaffe nedica l center.
Early neonatal sepsis requires rapid and efficient intervention to prevent morbidity and mortality. Management of such a case includes invasive blood examinations, elongation of maternal and neonatal length of stay, and empiric antibiotic therapy. These actions has major side effects. On 2017, Kaiser-Permanente started using a calculator that weighs the chances for early onset neonatal sepsis, and states the best investigation and follow-up regimn for the specific newborn infant. Eversince, policy of managing neonatal suspected early onset sepsis has chaged globally, including in Israel. Current knowledge regarding the local outcome since the use of the calculatir is scarce.
The goal of the study is to evaluate the change in management of suspected neonatal early onset sepsis, including its economic value, between periods before and after assimilation of the calculator in Hillel Yaffe nedical center.
192 studies on the registry are indexed under Neonatal Sepsis; 41 are open to participants now.
This study's planned enrollment of 6,300 is above the median of 200 across 85 observational studies indexed under Neonatal Sepsis.
Browse Neonatal Sepsis studies →Hillel Yaffe Medical Center is the lead sponsor of 305 studies on the registry; 10 are open to participants now.
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Newborn infants in Hillel Yaffe medical center
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Exclusion Criteria:
Newborn infants before assimilation of EOS calculator
Other: No intervention
Newborn infants after assimilation of EOS calculator
Other: No intervention
No intervention
Number of negative blood cultures out of all blood cultures
Total count of negative blood cultures out of all blood cultures in all patients in group
Time frame: during first week of life
Number of positive blood cultures
Total count of positive blood cultures in all patients in group
Time frame: during first week of life
Cost of treatment
Total cost of Blood cultures + Blood counts + Antibiotic therpy in all patients in group
Time frame: during first week of life
Plan to share: Undecided — Did not decide yet
Start is estimated for Dec 2026; primary completion for Jun 2027, 6 months later.
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This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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