An observational study in Sevoflurane, Propofol and Desflurane, sponsored by Shanghai 10th People's Hospital. Status unknown at 1 site in China. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2020-10-22.
Sponsored by Shanghai 10th People's Hospital · Observational
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Among 185 studies in Emergence Delirium with a site in China — 64 open to participants now, 65 under way, 1 of them phase 3. Emergence Delirium · China.
Among the 185 studies in Emergence Delirium with a site in China, this one is the 36th largest by planned enrollment of the 74 observational ones that give a count, is one of 5 that started in 2016, is one of 74 observational ones, and was the 21st registered.
752 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
Browse Emergence Delirium studies →64 of the 185 studies in Emergence Delirium with a site in China are open now. Recruiting first, the newest first:
The First Affiliated Hospital with Nanjing Medical University · Sites in China
Ages 65–85
Nanjing First Hospital, Nanjing Medical University · Sites in China
Ages 65–90 · Healthy volunteers
Peking University First Hospital · Sites in China
Ages 65+ · Healthy volunteers
Peking University People's Hospital · Sites in China
Ages 65+ · Healthy volunteers
Fujian Medical University Union Hospital · Sites in China
Ages 18+
A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →
Of the 143 Emergence Delirium studies recruiting now, 79 (55%) set no upper age limit and 44 (31%) stop at 75 or younger; 34 take children under 18; 24 take healthy volunteers.
This study: 60 Years and older · all sexes · no healthy volunteers.
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185 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 5 started in 2016.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 300 is above the median of 164 across 278 observational studies indexed under Emergence Delirium.
Median enrollment 225 across the 111 interventional studies, 300 across the 74 observational. Of the 74 that completed or were terminated, 2 (3%) have results posted.
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1 of 185 have an industry lead sponsor. The 10 most frequent:
Shanghai 10th People's Hospital is the lead sponsor of 167 studies on the registry; 45 are open to participants now.
Shanghai 10th People's Hospital has 3 studies filed under Emergence Delirium — fewer than ten, so there is no comparison to draw.
21 of the studies in Emergence Delirium with a site in China that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06361238Phase 3The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolLiraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery | 2027-03-31 |
| NCT07880938The First Hospital of Jilin UniversityIntranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension Laryngoscopy | 2026-12 |
| NCT07523334Peking University First HospitalImpact of Esketamine on Delayed Neurocognitive Recovery in Older Patients | 2026-12 |
| NCT07351474The First Affiliated Hospital with Nanjing Medical UniversityRemimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Gastrectomy | 2026-12-25 |
| NCT07394647The First Affiliated Hospital of Zhejiang Chinese Medical UniversityTranscutaneous Auricular Vagus Nerve Stimulation for Prevention of Emergence Agitation and Delirium in Children Undergoing Tonsillectomy and Adenoidectomy | 2026-12-30 |
Add all 21 to your calendar (.ics) → With an account.
Among the 185 studies in Emergence Delirium with a site in China, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and severity of POD/POCD, and POD/POCD is associated with retinal nerve fiber layer (RNFL) thickness, as well as Serum level of vitamin B12, folic acid, homocysteine and human myeloid differentiation protein-2 (MD-2s). The investigators plan to perform the studies in 300 participants at Shanghai 10th People's Hospital.
Postoperative delirium (POD) and postoperative cognitive disorder (POCD) are the most common complications of geriatric surgical patients, which could cause long-term social dysfunction, high mortality and increased medical cost. Currently, there is no efficient biomarker for POD/POCD, and it also remains largely unknown whether different anesthesia might lead to different incidence and severity of POD/POCD. The investigator's previous studies showed that thickness of retinal nerve fiber layer thickness (RNFL-T) measured by optical coherence tomography (OCT) was associated with POD/POCD; change of RNFL thickness (RNFL-C) in certain period correlated with cognitive deterioration. Thus, the investigators consider that RNFL might be a potential biomarker of POD/POCD. In the proposed large-scale longitudinal studies, the investigators will clinically validate RNF-LT as pre-operative POD/POCD biomarker, and RNFL-C as post-operative biomarker of POD/POCD. Finally, the investigators will compare the effects of surgery (total hip/knee replacement) under general anesthesia with sevoflurane, propofol and desflurane on the incidence and severity of POD/POCD in patients. Results from the proposed studies will likely establish RNFL as a potential POD/POCD biomarker, promote the clinical utilization of OCT-RNFL in early screening and outcome prediction of POD/POCD, and finally optimize anesthesia care of geriatric surgical patients to avoid or reduce POD/POCD incidence. These findings will lead to better postoperative outcomes of geriatric patients.
Patients, aged 60 years old or older, who admitted to the Department of Orthopedics at Shanghai 10th People's Hospital and had been scheduled to undergo knee or hip fractures were screened and asked to participate in the study.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients in Sevoflurane group are maintained with sevoflurane from an anesthesia machine through the laryngeal mask airway guided by Narcrotrend index monitoring.
Drug: Sevoflurane
Patients in Propofol group are maintained with propofol through intravenous administration guided by Narcrotrend index monitoring.
Drug: Propofol
Patients in Desflurane group are maintained with desflurane from an anesthesia machine through the laryngeal mask airway guided by Narcrotrend index monitoring.
Drug: Desflurane
Anesthesia maintenance with sevoflurane guided by Narcrotrend index monitoring.
Anesthesia maintenance with propofol guided by Narcrotrend index monitoring.
Anesthesia maintenance with desflurane guided by Narcrotrend index monitoring.
Postoperative delirium
Postoperative delirium will be determined by Confusion Assessment Method (CAM) at 1st postoperative day
Time frame: At 1st day after the surgery
Postoperative delirium
Postoperative delirium will be determined by CAM at 2nd postoperative day
Time frame: At 2nd day after the surgery
Postoperative delirium
Postoperative delirium will be determined by CAM at 3rd postoperative day
Time frame: At 3rd day after the surgery
Preoperative cognitive function
Preoperative cognitive function will be assessed by neuropsychological battery
Time frame: Preoperative cognitive function (baseline)
Postoperative cognitive dysfunction
Postoperative cognitive dysfunction will be assessed by neuropsychological battery before and after the surgery and anesthesia
Time frame: Change from baseline cognitive dysfunction at 1 week
Postoperative cognitive dysfunction
Postoperative cognitive dysfunction will be assessed by neuropsychological battery
Time frame: Change from baseline cognitive dysfunction at 3rd month
Retinal nerve fiber layer thickness
Retinal nerve fiberlayer（RNFL）thickness will be measured by optical coherence tomography (OCT) before and after surgery and anesthesia
Time frame: Change from baseline RNFL thickness at 3rd month
Serum level of vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s)
vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s) will be tested
Time frame: Before the surgery (baseline)
Serum level of vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s)
vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s) will be tested
Time frame: At 1st day after the surgery
Serum level of vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s)
vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s) will be tested
Time frame: At 2nd day after the surgery
Serum level of vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s)
vitamin B12, folic acid, homocysteine and myeloid differentiation protein-2 (MD-2s) will be tested
Time frame: At 3rd day after the surgery
Plan to share: Undecided
Started Jan 2016 (actual). Primary completion is estimated for Jun 2021, 65 months after the start.
Of 180 non-industry observational studies under Emergence Delirium, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's planned 65 months is above that.
Counting every sponsor, half of 180 studies reached it within 21 months; a quarter within 10 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Shanghai 10th People's Hospital →