An observational study in Coronary Atherosclerosis and Adipokines, sponsored by University Hospital, Ioannina. Status unknown at 1 site in Greece. Open to male participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-26.
Sponsored by University Hospital, Ioannina · Observational
The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
The aim of the study is to investigate whether the expression and production of four adipokines [adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.
Individuals undergoing cardiac surgery will be recruited in this study.
Exclusion Criteria:
Nondiabetics without significant stenoses (\> 50%) in the coronary arteries
Nondiabetics with significant stenosis in the left anterior descending (LAD) coronary artery or in the Left main (LM) coronary artery, but without significant stenosis in the right coronary artery (RCA)
Nondiabetics without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA
Nondiabetics with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA
Patients with type 2 diabetes mellitus (T2DM) without significant stenoses in the coronary arteries
T2DM patients with significant stenosis in the LAD or in the LM, but without significant stenosis in RCA
T2DM patients without significant stenosis in the LAD and in the LM, but with significant stenosis in the RCA
T2DM patients with significant stenosis in the LAD or in the LM and with significant stenosis in the RCA
Association between coronary artery disease and epicardial adipokines
Comparison of the mRNA and protein production of four adipokines \[adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)\] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups: 1. Cluster 1: NonDM-0 and DM-0 (comparison between territories that are supplied by non-stenosed coronary arteries) 2. Cluster 2: NonDM-LR and DM-LR (comparison between territories that are supplied by stenosed coronary arteries) 3. Cluster 3: NonDM-L, NonDM-R, DM-L and DM-R (comparison between a territory that is supplied by stenosed coronary artery and another territory that is supplied by non-stenosed coronary artery)
Time frame: Baseline measurement
Impact of diabetes on epicardial adipokines
Comparison of the mRNA and protein production of four adipokines (adiponectin, omentin-1, resistin, RBP4) from the epicardial adipose tissue of the territory that is supplied by LAD or RCA between the following groups: 1. NonDM-0 vs DM-0 2. NonDM-L vs DM-L 3. NonDM-R vs DM-R 4. NonDM-LR vs DM-LR
Time frame: Baseline measurement
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University Hospital, Ioannina