ClinicalTrials.gg
CompletedNCT03322267Updated Mar 6, 2026Results posted

Adjuvant Pembrolizumab for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma at High Risk of Recurrence

A Phase 2 interventional study of Pembrolizumab in Esophageal Squamous Cell Carcinoma, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2026-03-06.

Sponsored by National Taiwan University Hospital · Phase 2, Interventional, and Treatment

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Phase
Phase 2
Study type
Interventional
Enrollment
26
Allocation
Not applicable
Ages
20 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 17 studies testing pembrolizumab in Esophageal Squamous Cell Carcinoma — 5 open to participants now, 6 under way, 2 of them phase 3. pembrolizumab · Esophageal Squamous Cell Carcinoma.

Enrollment
14th of 17
26 · median 50
Started
2018
the only one that year
Phase 2
11 of 17
2 open now
Registered
4th of 17
by date
Lead sponsor
1 of 17
National Taiwan University Hospital

Among the 17 studies testing pembrolizumab in Esophageal Squamous Cell Carcinoma, this one is the 14th largest by enrollment, is the only one that started in 2018, is one of 11 in phase 2, and was the 4th registered.

Esophageal Squamous Cell Carcinoma

676 studies on the registry are indexed under Esophageal Squamous Cell Carcinoma; 267 are open to participants now.

Browse Esophageal Squamous Cell Carcinoma studies →

Open to participants now

5 of the 17 studies testing pembrolizumab in Esophageal Squamous Cell Carcinoma are open now, in 1 country. Recruiting first, the newest first:

By country, each count listing its studies:

All 5 open studies →

About pembrolizumab

pembrolizumab: first FDA approval 2014 (KEYTRUDA), first EMA approval 2015. What it is approved for, and how studies give it, is on its page →

Who these studies take

Of the 180 Esophageal Squamous Cell Carcinoma studies recruiting now, 83 (46%) set no upper age limit and 76 (42%) stop at 75 or younger; 3 take children under 18; 8 take healthy volunteers.

This study: 20 Years and older · all sexes · no healthy volunteers.

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 17 studies testing pembrolizumab in Esophageal Squamous Cell Carcinoma, or all of them as a file.
02

Study summary

In this study, participants with histologically diagnosed locally advanced esophageal squamous cell carcinoma who have received preoperative cisplatin-based chemoradiotherapy followed by surgery harbouring high risk of tumor recurrence will receive adjuvant cisplatin-based chemoradiotherapy followed by pembrolizumab. The primary study hypothesis is that adjuvant pembrolizumab will improve the 1-year recurrence-free survival rate compared to historical control.

Read the detailed description

It is a single-arm phase II trial. The target population is patients with histologically diagnosed locally advanced ESCC patients (clinically staged at least T3 and/or any N and M0 by endoscopic ultrasonography [EUS] and fludeoxyglucose-positron emission tomography [FDG-PET]) who have received preoperative cisplatin-based chemoradiotherapy (CRT) followed by surgery, and exhibit high risk (closed or involved resection margin or extranodal invasion of involved lymph nodes or ypN2-3) of tumor recurrence. Eligible patients will receive adjuvant cisplatin-based CRT followed by pembrolizumab for 18 cycles.The study will enroll 46 patients in Taiwan. The estimated enrollment period is 2 years.

03

Conditions studied

  • Esophageal Squamous Cell Carcinoma

Keywords

  • Adjuvant pembrolizumab
  • Chemoradiotherapy
04

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Be willing and able to provide written /assent for the trial.
  2. Be ≥ 20 years of age on day of signing informed consent.
  3. Be a diagnosed by pathology or cytology with a locally advanced ESCC, which is clinically stage according to the TNM system of the American Joint Committee on Cancer (AJCC) Cancer Staging System (7th edition), fulfilling one of the following criteria as determined by endoscopic ultrasound, computed tomography, bronchoscopy and positron emission tomography:

    1. T3, N0, M0;
    2. T4a, N0, M0;
    3. T1-4a, N1-3, M0.
  4. Have been treated with preoperative cisplatin-based CRT followed by esophagectomy with lymph node dissection for the locally advanced ESCC (defined by above criteria).
  5. Have a performance status of 0 or 1 on the Performance Scale.
  6. Exhibit at least one risk factor of tumor recurrence in the post-CRT surgical tissues:

    1. Close (≤1mm) or involved margin;
    2. Residual tumor cells in lymph nodes with extranodal invasion.
    3. ypN2 or ypN3.
  7. Adequate hemogram and organ function:

    1. ≥1,500 /mcL; ≥100,000 / mcL; ≥9 g/dL without transfusion or EPO dependency (within 7 days of assessment)
    2. Serum creatinine ≤1.5 X or measured or calculated ≥60 mL/min; serum total ≤ 1.5 X ULN; and ALT ≤ 2.5 X ULN; albumin >2.5 mg/dL; or prothrombin time and activated partial thromboplastin time ≤1.5 X ULN unless subject is receiving anticoagulant therapy
  8. Female subject of should have a negative urine or serum pregnancy within 72 hours prior to receiving the first dose of study medication. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
  9. Female subjects of childbearing potential must be willing to use an adequate method of . Contraception, for the course of the study through 120 days after the last dose of study medication.
  10. Male subjects of childbearing potential must agree to use an adequate method of contraception. Contraception, starting with the first dose of study therapy through 120 days after the last dose of study therapy.

Exclusion criteria

Exclusion Criteria:

  1. Is diagnosed with adenocarcinoma of esophagus or gastroesophageal junction.
  2. Has synchronously diagnosed with a squamous cell carcinoma of aero-digestive way, other than esophageal cancer.
  3. Has prior , except for: (a) adequately treated basal cell or squamous cell skin cancer; (b) in-situ cervical cancer; (c) previously diagnosed malignancy which have been adequately treated and shown no evidence of recurrence for more than 5 years.
  4. Is currently participating and receiving study therapy or has participated in a study of an agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment.
  5. Has a diagnosis of immunodeficiency or is receiving systemic therapy or any other form of therapy within 7 days prior to the first dose of trial treatment.
  6. Has a known history of active TB (Bacillus Tuberculosis)
  7. to pembrolizumab or any of its .
  8. Has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to a previously administered agent. Note: Subjects with ≤ Grade 2 neuropathy are an exception to this criterion and may qualify for the study. If subject received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting therapy.
  9. Has active disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment.
  10. Has known history of, or any evidence of active, non-infectious pneumonitis.
  11. Has an active infection requiring systemic therapy.
  12. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
  13. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
  14. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of trial treatment.
  15. Has received prior therapy with an , anti-PD-L1, or anti-PD-L2 agent.
  16. Has a known history of (HIV) (HIV 1/2 antibodies).
  17. virus positive subjects (defined as HBsAg positive and/or detectable HBV DNA).

    • Participants who are HBsAg positive are eligible if they have received HBV antiviral therapy for at least 4 weeks and have undetectable HBV viral load prior to enrollment.
    • Participants should remain on anti-viral therapy throughout study intervention and follow local guidelines for HBV anti-viral therapy post completion of study intervention.
  18. virus positive subjects (defined as anti-HCV Ab positive and detectable HCV RNA).

    • Participants with history of HCV infection are eligible if HCV viral load is undetectable at screening.
    • Participants must have completed curative anti-viral therapy at least 4 weeks prior to randomization.
  19. Concurrent active Hepatitis B (defined as HBsAg positive and/or detectable HBV DNA) and active Hepatitis C virus (defined as anti-HCV Ab positive and detectable HCV RNA) infection.
  20. Has received a within 30 days of planned start of study therapy. Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live attenuated vaccines, and are not allowed.
  21. Has received organ transplantation.
Terms in these criteria, in plain language(24)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

ECOG performance status

A scale of how much an illness limits everyday activity. For people being assessed to join a study, scores run from 0 (fully active) to 4; lower is more active.

0
Fully active, no restrictions.
1
Limited in strenuous activity, but walking and able to do light work, such as housework or office work.
2
Walking and able to look after yourself, but unable to work; up and about more than half of waking hours.
3
Able to look after yourself only in part; in bed or a chair more than half of waking hours.
4
Unable to look after yourself at all; in bed or a chair all day.

Studies most often ask for 0–1 or 0–2. Your doctor gives the score; the WHO scale uses the same steps. The full scale also has 5, which records death.

Absolute neutrophil count (ANC)

The number of neutrophils, white blood cells that help fight infection, in a given amount of blood. Too few raises the risk of infection.

It is a count, not a percentage of the white cells. Limits are written in units that mean the same: ≥ 1.5 × 10⁹/L is ≥ 1,500 per mm³ (µL). Each lab has its own reference range.

Platelets

Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.

Hemoglobin (Hb)

The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).

ULN (upper limit of normal)

The top of the normal range for a blood test, as set by the laboratory that runs it. Each lab prints its own range next to your result.

“≤ 2.5 × ULN” means the result can be up to two and a half times that top value.

Creatinine clearance (CrCl)

How quickly the kidneys clear creatinine, a waste product, from the blood. A study may estimate it from a blood test with age, weight and sex (often by the Cockcroft–Gault formula), or measure it using blood and urine collected over a set time. Given in mL/min; higher is better.

Bilirubin

A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.

Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.

ALT and AST (liver enzymes)

Two enzymes measured in a routine blood test of the liver. Higher levels can mean the liver is under strain or damaged. SGPT and SGOT are older names for ALT and AST.

Criteria usually give a limit as a multiple of the upper limit of normal (ULN), often higher when cancer has spread to the liver.

INR, PT and aPTT (clotting tests)

Blood tests of how long blood takes to clot. The INR is the prothrombin time (PT) put on a common scale; about 1 is usual for someone not taking a blood thinner.

Criteria often make an exception for people on a blood thinner such as warfarin, whose INR is raised on purpose.

Childbearing potential

Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).

Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

Investigational drug or device

A drug or device being studied in a clinical trial.

It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

Immunosuppression

A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.

Read whether the line is about a condition or about medicines, and which medicines and doses it means.

Hypersensitivity

An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.

Excipients

The other ingredients in a medicine besides the active drug, such as fillers, colours or preservatives.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

PD-1, PD-L1 and checkpoint inhibitors

PD-1, PD-L1 and CTLA-4 are proteins that act as brakes on the immune system. Checkpoint inhibitors, such as pembrolizumab or nivolumab, block them so the immune system can attack a cancer.

PD-L1 can also be measured in a tumour sample. Some scores count stained tumour cells only (TPS); others also count certain immune cells (CPS). The study names the score and the minimum it uses.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

Hepatitis B tests

Hepatitis B is a virus that infects the liver. These are separate tests: HBsAg positive usually means a current infection (a recent vaccination can briefly cause it too); total anti-HBc (HBcAb) positive means an infection now or in the past; HBV DNA measures how much virus is in the blood.

Some studies accept a past infection if HBV DNA is undetectable, sometimes with antiviral medicine during the study. Check what this study allows.

Hepatitis C tests

Hepatitis C is a virus that infects the liver. An HCV antibody test can stay positive after an infection has cleared (and is occasionally positive without one); an HCV RNA test shows whether the virus is there now.

After treatment, hepatitis C counts as cured when HCV RNA is still undetectable 12 weeks or more after the treatment ended. Studies often accept people cured this way.

Live vaccines

Vaccines made with a weakened form of the germ, such as measles–mumps–rubella (MMR), chickenpox and yellow fever. They can be risky when the immune system is weakened. Flu injections are not live; the nasal flu spray is.

05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
26 participants (actual)

Study arms

  • Experimental
    Pembrolizumab

    Adjuvant cisplatin-chemoradiotherapy followed by pembrolizumab

    Drug: Pembrolizumab

Interventions

  • Cisplatin (30 mg/m2, QW, 2 cycles) and radiotherapy (18-26 Gy/10-13 fractions) as adjuvant chemoradiotherapy, followed by pembrolizumab (200mg, Q3W, 18 cycles)

    Also known as: cisplatin, radiotherapy

06

What researchers measure

Primary outcomes

  1. 1-year Relapse-free Survival Rate

    From enrollment to relapse or death

    Time frame: up to 21.6 months

Secondary outcomes

  1. The Median RFS

    from enrollment to relapse or death

    Time frame: 21.6 months

  2. The Median Overall Survival (OS)

    Overall survival is from enrollment to death

    Time frame: 21.6 months

  3. The 3-year RFS Rate

    Recurrence-free survival is the time from enrollment to disease recurrence or the last follow-up (censored). Recurrence will be detected by regular image study (computed scan and esophagoscopy) every 3 months during the 1st to 3rd years then every 6 months during 4th and 5th years after esophagectomy. Response Evaluation Criteria in Solid Tumors 1.1 will be used for assessment.

    Time frame: 3 years

  4. The 3-year OS Rate.

    OS is the time from enrollment to death of any cause or the last follow-up (censored).

    Time frame: 3 years

  5. Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)

    Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

    Time frame: 3 years

Other outcomes

  1. Tissue-based Biomarkers

    To explore the tumor tissue-based biomarkers associated with tumor recurrence.

    Time frame: 3 years

  2. Blood-based Biomarkers

    To explore the blood-based biomarkers associated with tumor recurrence.

    Time frame: 3 years

07

Results

Posted Dec 19, 2024

Participant flow

Among the 88 patients screened at National Taiwan University Hospital, Taipei City, Taiwan, between October 2018 and December 2022, 25 were finally included in the present study (protocol defined 24 evaluable patients according to statistical hypothesis and total 26 as considering for drop-out rate) .

Participant flow — Overall Study
MilestonePembrolizumab
Started25
Completed11
Not completed14
Withdrew: Lack of efficacy11
Withdrew: Adverse event1
Withdrew: Withdrawal by subject2

Outcome measures

Primary1-year Relapse-free Survival Rate

From enrollment to relapse or death

Time frame:
up to 21.6 months
Reported as:
Median · months
1-year Relapse-free Survival Rate
monthsPembrolizumab
1-year Relapse-free Survival Rate14.3 (9.0 to 19.5)
SecondaryThe Median RFS

from enrollment to relapse or death

Time frame:
21.6 months

Results for this outcome have not been posted.

SecondaryThe Median Overall Survival (OS)

Overall survival is from enrollment to death

Time frame:
21.6 months

Results for this outcome have not been posted.

SecondaryThe 3-year RFS Rate

Recurrence-free survival is the time from enrollment to disease recurrence or the last follow-up (censored). Recurrence will be detected by regular image study (computed scan and esophagoscopy) every 3 months during the 1st to 3rd years then every 6 months during 4th and 5th years after esophagectomy. Response Evaluation Criteria in Solid Tumors 1.1 will be used for assessment.

Time frame:
3 years

Results for this outcome have not been posted.

SecondaryThe 3-year OS Rate.

OS is the time from enrollment to death of any cause or the last follow-up (censored).

Time frame:
3 years

Results for this outcome have not been posted.

SecondaryIncidence of Treatment-Emergent Adverse Events (Safety and Tolerability)

Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

Time frame:
3 years

Results for this outcome have not been posted.

Other pre-specifiedTissue-based Biomarkers

To explore the tumor tissue-based biomarkers associated with tumor recurrence.

Time frame:
3 years

Results for this outcome have not been posted.

Other pre-specifiedBlood-based Biomarkers

To explore the blood-based biomarkers associated with tumor recurrence.

Time frame:
3 years

Results for this outcome have not been posted.

Adverse events

Collected over I year. Non-serious events are listed at a 5% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Pembrolizumab17/25 (68%)5/25 (20%)9/25 (36%)
Most frequent serious events
Most frequent serious events
EventPembrolizumab
InfectionInfections and infestations2/25
ColitisGastrointestinal disorders1/25
LeucopeniaBlood and lymphatic system disorders1/25
PancreatitisGastrointestinal disorders1/25
Most frequent other events
Most frequent other events
EventPembrolizumab
LeucopeniaBlood and lymphatic system disorders9/25
InfectionInfections and infestations8/25
DiarrheaGastrointestinal disorders7/25
PneumonitisRespiratory, thoracic and mediastinal disorders6/25
FatigueGeneral disorders5/25
anemiaBlood and lymphatic system disorders5/25
thrombocytopeniaBlood and lymphatic system disorders3/25

Baseline characteristics

Age, Customized
Age, Customized(years)Pembrolizumab
Median age62.3 (43.3 to 73.1)
Sex/Gender, Customized
Sex/Gender, Customized(participants)Pembrolizumab
Male22
female3
Race/Ethnicity, Customized
Race/Ethnicity, Customized(participants)Pembrolizumab
Asian25
Region of Enrollment
Region of Enrollment(participants)Pembrolizumab
Taiwan25
08

Study locations

1 site
  • National Taiwan University Hospital
    Taipei, 10002, Taiwan
09

References and documents

Publications

  • Guo JC, Huang TC, Kuo HY, Lin CC, Hsu FM, Cheng JC, Huang YL, Hsieh MS, Huang PM, Lee JM, Wu SL, Hsu CH. Adjuvant chemoradiotherapy plus pembrolizumab for locally advanced esophageal squamous cell carcinoma with high risk of recurrence following neoadjuvant chemoradiotherapy: a single-arm phase II study. Cancer Immunol Immunother. 2024 Sep 9;73(11):230. doi: 10.1007/s00262-024-03826-y. PubMed 39249605 ↗

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

10

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Oct 2018 to primary completion in Jan 2024, 63 months.

Results were first posted in Dec 2024, 10 months after primary completion.

Of 153 non-industry phase 2 interventional studies under Esophageal Squamous Cell Carcinoma, half reached primary completion within 41 months of starting (the median), counting those still running; a quarter within 30 and three quarters within 55. This study's 63 months is above that.

Counting every sponsor, half of 173 studies reached it within 40 months; a quarter within 28 and three quarters within 52.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 16, 2017
First posted
Oct 26, 2017
StartActual
Oct 27, 2018
Primary completionActual
Jan 31, 2024
CompletionActual
Jan 30, 2026
Results first posted
Dec 19, 2024
Last update
Mar 6, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Mar 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
11

Registry details

Key details

Study ID
NCT03322267
Responsible party
Sponsor
First posted
Oct 26, 2017
Start date
Oct 27, 2018
Primary completion
Jan 31, 2024
Completion
Jan 30, 2026
Results posted
Dec 19, 2024
Last update
Mar 6, 2026

Study contacts

Chih-Hung Hsu, MD, PhD
principal investigator · National Taiwan University Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

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Studies of the drug tested here: Pembrolizumab

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