CClinicalTrials.gg
CompletedNCT03305679Updated Jul 30, 2018

Clinical Efficacy of the Immediate Implant Loading

An interventional study of Direct provisional technique and Indirect Provisional technique in Implant Site Reaction, sponsored by Damascus University. Completed at 3 sites in 2 countries. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-30.

Sponsored by Damascus University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
20 Years to 40 Years
Sex
All
01

Study summary

Aim: The aim of this study to Assess the healing process of the immediate implant loading with two different provisional techniques (direct and indirect).

Materials and methods:

20 implant in the aesthetic zone either in the incisor or in the canine area and excluding the lateral location and then immediate loading is achieved for the 20 implants (10 for direct and 10 for indirect method) Clinical Aspect :color change , healing and bone resorption Esthetic assessment and patient acceptance will be assessed using specific tools.

Lab aspect: surface roughness and Marginal fit will be measured to have clue vision.

Read the detailed description

Aim: The aim of this study to Assess the healing process of the immediate implant loading with two different provisional techniques (direct and indirect).

Materials and methods:

20 implant (Implant Direct ) in the aesthetic zone either in the incisor or in the canine area and excluding the lateral location and then immediate loading is achieved for the 20 implants (10 for direct and 10 for indirect method) Clinical Aspect :color change , healing and bone resorption Aesthetic assessment and patient acceptance will be assessed using specific tools Lab aspect: surface roughness and Marginal fit will be measured to have clue vision.

The participants were non-dental students from University colleges in and around Damascus. They were recruited by reviewing the case documents 20 patient with hapless incisal and canine for extraction and immediate implantation and immediate loading with either the two different provisional methods participants had to demonstrate a hopeless central incisor or canine with no perio-active infection. With two types of provisional technique we will have a two groups were calculated a priori in such a way that index can be identified with with alpha = .05 in a two-tailed test, a sample size of 2 X10 implants would result in a power of 94% (g power 3.1.3) based on a pilot study.

Cone-beam computed tomography (CBCT) images for each patient to measure the bone level change and aesthetic assessment by three general dentists will be achieved. Replica technique required the application of impression material build up of addition-silicone. Addition-silicone of very low viscosity (ExpressTM2 Ultra-Light Body Quick) was applied to all restorations interior, after which the crowns were set onto basic samples. Impression material was polymerized within the time which is recommended by the manufacturer, while the pressure force of 50 N was applied toward occlusal direction After the removal of all restorations from the basic samples, the layer of impression material remained on the restoration's inner surface due to its higher roughness compared to the abutment surface. With Rt 200 device the roughness will bw measured and then Scanning Electronic Microscope (SEM) images will give a close understanding of the surface. Easy shade will measure the color change.

02

Conditions studied

  • Implant Site Reaction
03

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  1. esthetic request.
  2. either incisor or canine indicated for extraction.
  3. symmetrical gingival level.
  4. no active periodontal disease.
  5. age between 20-40 years old

Exclusion criteria

Exclusion Criteria:

  1. Lateral hopeless tooth .
  2. Active periodontal lesion .
  3. loss of periodontal tissue .
  4. missed incisor or missed canine in the area of implantation.
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Outcomes assessor)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    Direct provisional technique

    Patients here will be subjected to the direct provisional technique

    Procedure: Direct provisional technique

  • Active comparator
    Indirect Provisional technique

    Patients here will be subjected to the indirect provisional technique

    Procedure: Indirect Provisional technique

Interventions

  • ProcedureDirect provisional technique

    The method of implantation will be accomplished directly.

  • ProcedureIndirect Provisional technique

    The method of implantation will be accomplished indirectly.

05

What researchers measure

Primary outcomes

  1. Change in alveolar bone level

    This will be measured using cone-beam computed tomography images

    Time frame: T1: at one day after implantation, T2: at one month following implantation, T2: at two months following implantation, T3: at three months following implantation

  2. Change in the Gingival Index

    This will be measured using the the gingival index

    Time frame: T1: at one day after implantation, T2: at one month following implantation, T2: at two months following implantation, T3: at three months following implantation

  3. Change in Esthetic Appearance

    This will be measured by using the White Esthetic Scale (WES)

    Time frame: T1: at one day before implantation, T2: at three months following implantation

  4. Change in the Plaque Index

    This will be measured using the the plaque index

    Time frame: T1: at one day after implantation, T2: at one month following implantation, T2: at two months following implantation, T3: at three months following implantation

  5. Change in the Pink Esthetic Scale

    This will be measured using the Pink Esthetic Scale

    Time frame: T1: at one day after implantation, T2: at one month following implantation, T2: at two months following implantation, T3: at three months following implantation

Secondary outcomes

  1. Change in Restoration Color

    This will be measured using a standardized color guide

    Time frame: T1: at one day after implantation, T2: at one month following implantation, T2: at two months following implantation, T3: at three months following implantation

06

Study locations

3 sites
  • Department of Oral Implantology -Sante Jousef University - School of Dental Medicine
    Beirut, Lebanon
  • Department of Fixed Prosthodontics, University of Damsacus
    Damascus, DM20AM18, Syrian Arab Republic
  • Nano Physical lab and biomaterial Lab - College of Applied Sciences
    Damascus, Syrian Arab Republic
07

References and documents

Publications

  • Friberg B. Bone augmentation for single tooth implants: A review of the literature. Eur J Oral Implantol. 2016;9 Suppl 1:S123-34. PubMed 27314117 ↗
  • Sanchez-Siles M, Munoz-Camara D, Salazar-Sanchez N, Camacho-Alonso F, Calvo-Guirado JL. Crestal bone loss around submerged and non-submerged implants during the osseointegration phase with different healing abutment designs: a randomized prospective clinical study. Clin Oral Implants Res. 2018 Jul;29(7):808-812. doi: 10.1111/clr.12981. Epub 2016 Sep 5. PubMed 27596682 ↗
  • Stoupel J, Lee CT, Glick J, Sanz-Miralles E, Chiuzan C, Papapanou PN. Immediate implant placement and provisionalization in the aesthetic zone using a flapless or a flap-involving approach: a randomized controlled trial. J Clin Periodontol. 2016 Dec;43(12):1171-1179. doi: 10.1111/jcpe.12610. Epub 2016 Oct 17. PubMed 27501953 ↗
  • Sethi A, Kaus T. Immediate Replacement of Single Teeth With Immediately Loaded Implants: Retrospective Analysis of a Clinical Case Series. Implant Dent. 2017 Feb;26(1):30-36. doi: 10.1097/ID.0000000000000512. PubMed 27902498 ↗
  • Zhang S, Wang S, Song Y. Immediate loading for implant restoration compared with early or conventional loading: A meta-analysis. J Craniomaxillofac Surg. 2017 Jun;45(6):793-803. doi: 10.1016/j.jcms.2016.05.002. Epub 2016 May 14. PubMed 28351528 ↗
  • Abdel-Azim T, Rogers K, Elathamna E, Zandinejad A, Metz M, Morton D. Comparison of the marginal fit of lithium disilicate crowns fabricated with CAD/CAM technology by using conventional impressions and two intraoral digital scanners. J Prosthet Dent. 2015 Oct;114(4):554-9. doi: 10.1016/j.prosdent.2015.04.001. Epub 2015 Jun 20. PubMed 26100929 ↗
  • Varol S, Kulak-Ozkan Y. In Vitro Comparison of Marginal and Internal Fit of Press-on-Metal Ceramic (PoM) Restorations with Zirconium-Supported and Conventional Metal Ceramic Fixed Partial Dentures Before and After Veneering. J Prosthodont. 2015 Jul;24(5):387-93. doi: 10.1111/jopr.12229. Epub 2014 Oct 1. PubMed 25274041 ↗
  • Renne W, Wolf B, Kessler R, McPherson K, Mennito AS. Evaluation of the Marginal Fit of CAD/CAM Crowns Fabricated Using Two Different Chairside CAD/CAM Systems on Preparations of Varying Quality. J Esthet Restor Dent. 2015 Jul-Aug;27(4):194-202. doi: 10.1111/jerd.12148. Epub 2015 Jul 14. PubMed 26177118 ↗
  • Louropoulou A, Slot DE, Van der Weijden F. Influence of mechanical instruments on the biocompatibility of titanium dental implants surfaces: a systematic review. Clin Oral Implants Res. 2015 Jul;26(7):841-50. doi: 10.1111/clr.12365. Epub 2014 Mar 19. PubMed 24641774 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03305679
Lead sponsor
Damascus University
Collaborators
St Joseph University, Beirut, Lebanon, Syrian Atomic Energy Agency, Damascus, Syria
Responsible party
Sponsor
First posted
Oct 10, 2017
Start date
Jan 19, 2017
Primary completion
Jan 19, 2018
Completion
Jul 19, 2018
Last update
Jul 30, 2018

Study contacts

Anas Abdo, DDS MSc
principal investigator · PhD student in Fixed Prosthodontics, Department of Fixed Prosthodontics, University of Damascus Dental School
Osama Yousuf Solieman, DDS MSc PhD
study director · Laboratoire Bioinge Ânierie et Nanosciences EA4203, Montpellier University, Montpellier, France
Christian Makary, DDS MSc PhD
study director · Professor of Oral Implantology, Sante Jousef University, School of Dental Medicine, Beirut, Lebanon
Mirza Allaf, DDS MSc PhD
study chair · Professor of Fixed Prosthodontics, University of Damascus Dental School, Damascus, Syria

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion