An interventional study of multimodal imaging in Knee Osteoarthritis, Joint Disease and Arthritis, sponsored by Centre Hospitalier Régional d'Orléans. Completed at 2 sites in France. Open to participants aged 45 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-11-28.
Sponsored by Centre Hospitalier Régional d'Orléans · Not applicable, Interventional, and Prevention
Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone. The aim of the present project is to determine predictive factors of progression of osteoarthritis at the knee by a multimodal characterization of subchondral bone by Medical Resonnance Imaging, direct high resolution digitization radiographs and bone texture analysis. At the end of the project, an innovative imaging device, combining semi-automatic softwares for texture analysis, control detection and image registration would be supplied. This will enable on the one hand a more accurate and reproducible way to measure the joint space width of the affected compartment and on the other hand, an assistance to better detect patients at risk of progression of their knee osteoarthritis. Identifying These "progressors" patients might permit their selection in clinical trials at baseline adapted to their severe disease, using for example biologic treatments targeting knee osteoarthritis. The main objective of this study is to analyze the predictive capacities of bone texture parameters measured on the high-resolution radiography of the knee on the structural evolution of the knee osteoarthritis at 3 years.
Exclusion Criteria:
multimodal imaging and clinical assessment
Diagnostic Test: multimodal imaging
Also known as: clinical assessment
Proportion of patients who have one-point increase in the quality score of OARSI
Patients who over the 3-year follow-up period will have a one-point increase in the quality score of OARSI compared to the initial pinch score (Altman RD et al, Osteoarthritis and Cartilage 1995).
Time frame: 3 years
Proportion of patients whose joint space reduction is greater than the smallest reliable detectable difference.
Patients whose joint space reduction is greater than the smallest reliable detectable difference.
Time frame: 3 years
Proportion of patients who have a decrease in joint space of 0.5 mm
Patients who have a decrease in joint space of 0.5 mm or more over the 3-year period (Cooper C et al, CMRO 2012).
Time frame: 3 years
Proportion of patients who have evolution of medial femoral tibial joint space
Evolution of medial femoral-tibial joint space
Time frame: 3 years
Number of particpants who will have evolution of strucutral lesion score
Evolution structural lesion score is OARSI (OsteoArthritis Research Society International score)
Time frame: 3 years
Evolution of algo-functional scores (OAKHQOL)
OAKHQOL (OsteoArthritis of Knee and Hip Quality Of Life) scores
Time frame: 3 years
Evolution of algo-functional scores (WOMAC)
WOMAC (McMaster Western Ontario questionnaire ) scores
Time frame: 3 years
Change From Baseline in quality of life Scores
Short Form 36
Time frame: 3 years
Change From Baseline in Pain Scores on the Visual Analog Scale
Pain visual analogical score
Time frame: 3 years
Plan to share: No
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Régional d'Orléans