CClinicalTrials.gg
CompletedNCT03271294Updated Sep 5, 2017

Prospective Performance Analysis of the Exair(TM) Prolapse Repair System in the Treatment of Pelvic Organ Prolapse

An interventional study of Exair Transvaginal Mesh in Pelvic Organ Prolapse, sponsored by Michigan Institution of Women's Health PC. Completed. Open to female participants, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-05.

Sponsored by Michigan Institution of Women's Health PC · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Not applicable
Sex
Female
01

Study summary

The aim of the study was to assess the role of the Exair transvaginal mesh system to correct pelvic organ prolapse from a subjective and objective standpoint. Subjects treated with the Exair transvaginal mesh for prolapse between June 2013 and August 2015 was analyzed. Subjects with uterine prolapse underwent vaginal mesh hysteropexy. There were no hysterectomies done for uterine prolapse in this study. A composite score that included subjective criteria of absence of a bothersome bulge, no prolapse below the hymen and no retreatment was used to assess success.Transvaginal Exair mesh hysteropexy offers a good option for the management of large uterine prolapses precluding the need for a hysterectomy.

02

Conditions studied

  • Pelvic Organ Prolapse

Keywords

  • pelvic organ prolapse
  • Exair
  • Transvaginal mesh
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • subjects desiring surgery for stage II or greater prolapse on the Pelvic Organ Prolapse Quantification System Assessment (POP-Q) and symptoms specific to pelvic organ prolapse mainly bothersome perception of a vaginal bulge

Exclusion criteria

Exclusion Criteria:

  • any physical or mental limitation that precluded their participation or inability to give informed consent
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
80 participants (actual)

Study arms

  • Other
    Exair transvaginal mesh surgery

    This is a prospective study done in 80 consecutive subjects who underwent the Exair transvaginal mesh surgery from June 2013 to August 2015. The subjects were followed at 4 weeks, 6 months and 12 months post-operatively. All eligible subjects underwent a detailed urogynecologic history and examination including a Pelvic Organ Prolapse Quantification system assessment (POP-Q).

    Device: Exair Transvaginal Mesh

Interventions

  • DeviceExair Transvaginal Mesh

    Exair transvaginal mesh system for the treatment of pelvic organ prolapse

05

What researchers measure

Primary outcomes

  1. Exair transvaginal mesh procedure success in anatomy and function at 1 year

    Subjects who underwent the Exair transvaginal mesh surgery were followed post-operatively to determine mesh procedure success at 12 months. A composite score that included subjective criteria of absence of a bothersome bulge, no prolapse below the hymen and no retreatment was used to assess success. Subjects treated with the Exair transvaginal mesh for prolapse between June 2013 and August 2015 was analyzed. The aim of the study was to assess the role of the Exair transvaginal mesh system to correct pelvic organ prolapse from a subjective and objective standpoint.

    Time frame: 1 year

06

Study locations

No study locations are listed for this record.

07

Registry details

Key details

Study ID
NCT03271294
Lead sponsor
Michigan Institution of Women's Health PC
Collaborators
Coloplast A/S
Responsible party
Salil Khandwala MD (Director of Urogynecology, Michigan Institution of Women's Health PC) — Principal investigator
First posted
Sep 5, 2017
Start date
Apr 19, 2013
Primary completion
Aug 2015
Completion
Aug 2015
Last update
Sep 5, 2017

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.

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