A Phase 2 interventional study of Nigella Sativa Oil and Normal saline in Chronic Periodontitis, sponsored by University of Health Sciences Lahore. Status unknown at 1 site in Pakistan. Open to participants aged 19 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-01.
Sponsored by University of Health Sciences Lahore · Phase 2, Interventional, and Health services research
Periodontitis is an infectious inflammatory disease affecting the periodontal tissue (Gingivae, alveolar bone, periodontal ligament and cementum). Chronic Periodontitis is considered to be the most prevalent disease after dental caries which is linked to increased levels of C- reactive protein, interleukins and matrix metallo-proteinases. Interleukin- 1β and Matrix metalloproteinase-8 have been shown to be robust markers of inflammatory cascade of chronic periodontitis.Various treatment modalities including scaling and root planing, toothpastes and chlorhexidine based mouthwashes have been are known to be associated with various side effects like teeth staining, altered taste sensation, mucosal burning. Hence,the use of natural medicaments could provide a better alternative because of their fewer side effects and cost effectiveness.
Periodontal disease is one of the most common diseases in humans and is responsible for most of the tooth loss in adults. World health Organisation report of 2005 described that the global problem persisted with the worldwide oral diseases such as dental caries, periodontal disease, tooth loss, oral mucosal lesions and oro-pharyngeal cancer. According to a local study the prevalence of periodontitis is found to be more in males of older age group and more in rural areas owing to the lack of awareness of importance of oral hygiene.
Apart from various conventional treatment option for periodontitis a number of herbal medicinal intervention have been used for its treatment. Plant extracts and herbs that have been used previously used for periodontal therapy include Salvadora persica, Arnica Montana and Hamamelis virginiana which have been shown to exhibit antibacterial activity against periodonto-pathic bacteria. Phytomedicines (Medicines derived from herbal plants) like indian gum arabic, aloe vera, nim, carvacrol, garlic, wild coffee and propolis resin have been used in dentistry as anti-inflammatory, antibiotics, analgesic and hypnotic agents. Propolis resin, guava and triphala have been also been used for the treatment of periodontitis
Exclusion Criteria:
The group contains healthy individuals with chronic periodontitis who will receive Normal Saline as placebo
Drug: Normal saline
The group contains healthy individuals with chronic periodontitis who will receive Nigella sativa Oil as intervention
Drug: Nigella Sativa Oil
The individuals will apply 55 drops of Nigella sativa Oil on gingivae twice daily for two weeks
Also known as: Black seed Oil
The individuals will apply 55 drops of Normal saline on gingivae twice daily for two weeks
Also known as: Saline
Levels of IL 1-Beta and MMP-8
These inflammatory marker will be measured in patients saliva again after 2 weeks. There will be reduction in their levels.
Time frame: 2 weeks
Plan to share: No — Data sharing will be considered after the completion of studies
This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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University of Health Sciences Lahore