An interventional study of repetitive magnetic stimulation in Dysphagia, Parkinson Disease and Swallowing Disorder.Other Specified, sponsored by University of Manchester. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-06-09.
Sponsored by University of Manchester · Not applicable, Interventional, and Treatment
This study will explore the effects of 3 different neurostimulation methods on swallowing function in patients with dysphagia secondary to Parkinson's Disease
The aim of this study is to assess 3 novel neuromodulation approaches - namely, pharyngeal stimulation, high frequency (5Hz) repetitive transcranial magnetic stimulation and low frequency (1Hz) repetitive transcranial magnetic stimulation on swallowing function in patients with dysphagia after Parkinson's Disease. A total of 66 patients are planned to be recruited, randomised to one of the 3 technologies or a sham treatment. A single treatment will be given and the effects will be assessed with a barium exam called videofluoroscopy within the 1st hour after the treatment. In addition, some measures of brain function will be recorded, before and after the treatments using single pulse transcranial magnetic stimulation.
723 studies on the registry are indexed under Deglutition Disorders; 219 are open to participants now.
This study's enrollment of 12 is below the median of 60 across 482 interventional studies indexed under Deglutition Disorders.
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Confirmed Parkinson's Disease with dysphagia
Exclusion Criteria:
Contraindications to magnetic stimulation, such as pacemakers, significant neuroleptic medications, pregnancy Other causes for dysphagia Unable to give informed written consent
Pharyngeal stimulation given at 5Hz for 10 minutes
Device: repetitive magnetic stimulation
repetitive transcranial magnetic stimulation at 1Hz applied for 600 pulses
Device: repetitive magnetic stimulation
repetitive transcranial magnetic stimulation at 5Hz applied for 600 pulses
Device: repetitive magnetic stimulation
Sham repetitive transcranial magnetic stimulation using the coil tilt technique
Device: repetitive magnetic stimulation
Neurostimulation
Also known as: pharyngeal stimulation
Videofluoroscopy
Changes in penetration aspiration scale
Time frame: 1 hour
Brain excitability
Measures of brain function to single pulse TMS
Time frame: Immediately after, 30 and 60 minutes
Plan to share: Undecided — Anonymized swallowing physiology data
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This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
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