An interventional study of Culture with progesterone and Culture without progesterone in Obstetric Labor, Premature, sponsored by Hillel Yaffe Medical Center. Completed at 1 site in Israel. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-06-23.
Sponsored by Hillel Yaffe Medical Center · Not applicable, Interventional, and Basic science
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
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This study's enrollment of 115 is above the median of 84 across 1,689 interventional studies indexed under Premature Birth.
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Exclusion Criteria:
IMC cells taken from preterm labor placentas after delivery will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with progesterone
IMC cells taken from term labor placentas after delivery will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with progesterone
IMC cells taken from preterm labor placentas after delivery will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture without progesterone
IMC cells taken from term labor placentas after delivery will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture without progesterone
IMC cells taken from term labor placentas from women that were treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with growth factors
IMC cells taken from preterm labor placentas from women that were treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with growth factors
IMC cells taken from term placentas from women who were not treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with growth factors
IMC cells taken from preterm placentas from women who were not treated with progesterone during pregnancy will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with growth factors
CD-14+ monocyte cells taken from women delivering at term will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with progesterone
CD-14+ monocyte cells taken from women delivering preterm will be cultured with progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture with progesterone
CD-14+ monocyte cells taken from women delivering at term will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture without progesterone
CD-14+ monocyte cells taken from women delivering preterm will be cultured without progesterone and will be analyzed for inflammation characteristics and maturation into DC cells.
Biological: Culture without progesterone
Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells
Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone
Culture of placental IMC cells with growth hormones only and analysis
Inflammation characteristic effects of progesterone on preterm and term placentas
Differences observed in cytokine profiles of IMC cells from term and preterm placentas cultured with and without progesterone
Time frame: One year
Maturation effects of progesterone on preterm and term placentas
Differences observed in maturation of IMC cells into DC cells in term and preterm placentas
Time frame: One year
Plan to share: No
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This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
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Hillel Yaffe Medical Center