An observational study in Lung Function, sponsored by Cynthia McEvoy. Not yet recruiting. Per ClinicalTrials.gov, last updated 2026-10-06.
Sponsored by Cynthia McEvoy · Observational
The purpose of the study is to learn more about extended continuous positive airway pressure (eCPAP) in preterm infants that may be helpful for lung health. We are hoping to find out if eCPAP in stable preterm infants in the NICU results in long lasting improvements of lung function in school aged children.
This is an observational follow-up of former preterm children from the eCPAP radnomized controlled trial (NCT#04295564), a single-center study of eCPAP vs discontinue CPAP (dCPAP) in the neonatal intensive care unit at Oregon Health \& Science University (OHSU). All former preterm infants randomized in the parent study will be approached for reconsent into this follow-up study. We will determine if eCPAP for stable preterm infants in the NICU results in sustained improvement of lung function (primary outcome spirometry) and less respiratory morbidity (wheeze), at school age. We will determine if eCPAP in the NICU results in an airway tree with a larger cross- sectional area and greater lung volume at school age, which is associated with less respiratory morbidity. Additionally, we will obtain detailed biological data (DNA methylation and transcriptomics using nasal epithelium as a proxy for airway epithelium), to identify participants that share common molecular signatures (biological endotypes).
2,554 studies on the registry are indexed under Premature Birth; 498 are open to participants now.
This study's planned enrollment of 95 is below the median of 112 across 777 observational studies indexed under Premature Birth.
Browse Premature Birth studies →Cynthia McEvoy is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
This is an observational follow-up study of former preterm infants who participated in the randomized clinical trial extended CPAP "parent study."
Exclusion Criteria:
Group that was assigned to Extended CPAP (eCPAP)
Other: Extended CPAP (eCPAP)
Group that was assigned to discontinue CPAP (dCPAP)
Assigned to two extra weeks of CPAP
Also known as: Treatment length
Sustained improvement of lung function (functional outcomes)
Determine if eCPAP for preterm infants in the NICU results in sustained improvement of lung function (primary outcome spirometry) and less respiratory morbidity (wheeze) at school age.
Time frame: Between the ages of 6 and 8
Airway tree changes (structural outcomes)
Determine via a single low dose high resolution computed tomography (HRCT) of the chest if eCPAP in the NICU results in an airway tree with a larger cross-sectional area and greater lung volume at school age, which is associated with less respiratory morbidity.
Time frame: Between the ages of 6 and 8
Molecular Endotypes
Detailed biological data (DNA methylation and transcriptomics using nasal epithelium as a proxy for airway epithelium), will be used to identify patients that share common molecular signatures (biological endotypes).
Time frame: Between the ages of 7 and 8
No study locations are listed for this record.
Plan to share: Undecided
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.