A Phase 3 interventional study of Pregabalin and Gabapentin in Herpetic Neuralgia, sponsored by Second Affiliated Hospital of Guangzhou Medical University. Status unknown at 1 site in China. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2017-06-14.
Sponsored by Second Affiliated Hospital of Guangzhou Medical University · Phase 3, Interventional, and Prevention
Pregabalin is effective on herpetic neuralgia, but whether can prevention post-herpetic neuralgia still need to confirm.
Pregabalin has been recommended as the first-line drug for post-herpetic neuralgia (PHN) therapy currently due to its efficacy and safety. However,there was no valuable report at present on the clinical efficacy of pregabalin for acute and subacute herpetic neuralgia (SHN), expect for a smaller study which included 29 outpatients who had acute zoster pain for a period of 7-1 4 days. And it is not clear whether early application of pregabalin can reduce the incidence of PHN.
Therefore, this study was rational designed to evaluate the efficacy and safety of pregabalin in the treatment of herpetic neuralgia，and follow-up to the 8 months, evaluation whether impacting the accidence of PHN.
It is the first time in the international that treating acute herpetic neuralgia (AHN) and SHN with pregabalin as a large sample size clinical trial. The results of this study will be great significance for guiding the clinical medication.
1,287 studies on the registry are indexed under Neuralgia; 256 are open to participants now.
This study's planned enrollment of 342 is above the median of 52 across 973 interventional studies indexed under Neuralgia.
Browse Neuralgia studies →Second Affiliated Hospital of Guangzhou Medical University is the lead sponsor of 69 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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experiment group: pregabalin 300mg,q12h for 6 months
Drug: Pregabalin
compared to pregabalin effect on herpetic neuralgia
Drug: Gabapentin
Pregabalin was taken 300mg,q 12h for 6 month.
Also known as: pregabalin tablet
Gabapentin was taken 0.4, tid for 6 month.
Also known as: gabapentin tablet
the changes of numerical rating scale (NRS)
Pain intensity was rated on an 1 1-point numerical rating scale
Time frame: from the date of start to 8 month
Brief Pain Inventory (BPI)
quality of life was rated on Brief Pain Inventory
Time frame: baseline and 8th month
Plan to share: No
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This study is status unknown, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Guangzhou Medical University