A Phase 3 interventional study of Methylene blue and Giemsa stain in Herpes Simplex, Herpes Zoster and Varicella Zoster, sponsored by Chulalongkorn University. Status unknown at 1 site in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-08-04.
Sponsored by Chulalongkorn University · Phase 3, Interventional, and Diagnostic
To compare the sensitivity of Tzanck smear with methylene blue stain versus traditional Giemsa stain in patients with herpes infection.
A smear from the lesional skin of the patients suspected having Herpes simplex, Herpes zoster and Varicella zoster skin infections will be collected (in a clinical routine setting). The specimen will be stained with methylene blue in addition to the Giemsa stain. Polymerase chain reaction study for herpes antigen will be performed in some of the specimens. The sensitivity, specificity, positive predictive value and negative predictive value will be calculated from the results of the study.
305 studies on the registry are indexed under Herpes Simplex; 31 are open to participants now.
This study's planned enrollment of 150 is above the median of 101 across 227 interventional studies indexed under Herpes Simplex.
Browse Herpes Simplex studies →Chulalongkorn University is the lead sponsor of 312 studies on the registry; 59 are open to participants now.
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Exclusion Criteria:
Patients who clinically diagnosed as herpes simplex, herpes zoster or varicella zoster skin infection.
Diagnostic Test: Methylene blue · Diagnostic Test: Giemsa stain
Patients who develops vesicular lesion but not typically considered as herpesviral skin infection, such as acute eczema, Paederus dermatitis
Diagnostic Test: Methylene blue · Diagnostic Test: Giemsa stain
working solution methylene blue
working solution Giemsa stain (Wolbach's modification)
Sensitivity
Positive results from staining compared with number of cases
Time frame: 24 weeks
Factors that contribute the results from Methylene blue staining
Subgroup analysis which included age, sex, clinical morphology, distribution, duration of lesion.
Time frame: 24 weeks
Specificity
Time frame: 24 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Chulalongkorn University