An observational study in Bacteremia and Infective Endocarditis, sponsored by Central Hospital, Nancy, France. Completed at 8 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-03-19.
Sponsored by Central Hospital, Nancy, France · Observational
To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li classification in a Population of adults suspected of infective endocarditis.
Hospitalized adult patients suspected of infective endocarditis
Exclusion Criteria:
Each patient experiences two methods of blood cultures.
Procedure: Blood Culture
For each patient, one single high volume blood culture (3 aerobic and 3 anaerobic of 8 to 10 mL each, numbered), and then 2 samples of 16 to 20 mL (one aerobic bottle and one anaerobic for each sample).
Compared performance of a single high volume blood culture vs. multiple blood culture of usual volume for the diagnosis of infective endocarditis
Sensitivity/Specificity/Accuracy of positive bloodculture sets vs. final diagnosis assessed by the medical team (gold standard)
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
Diagnostic performance of the single high volume blood culture for the diagnosis of infective endocarditis
according to the level of suspicion of infective endocarditis, the type of microorganism involved, the underlying cardiopathy.
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
Measuring the nursing time required for both sampling methods.
Time for blood culture setting, processing and sending
Time frame: At T0, i.e. at the inclusion of the patient
Diagnosis of infective endocarditis: confirmed, possible or excluded
Applying the Classification of Duke-Li according to the modified diagnostic criteria of the European Society of Cardiology Recommendations 2015.
Time frame: At the end of the hospitalization, or at the time of death if occurred during hospitalization; i.e. an average of 6 weeks after the inclusion
Plan to share: No
This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.
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Central Hospital, Nancy, France