An observational study in Asthma (Diagnosis), sponsored by Central Hospital, Nancy, France. Not yet recruiting. Open to participants aged 5 Years to 16 Years. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Central Hospital, Nancy, France · Observational
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during bronchoconstriction induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance during an ECT.
Oscillometry is a pulmonary function testing technique that is well suited to children who have difficulty cooperating with conventional tests such as spirometry, as it is performed during spontaneous breathing and does not require specific respiratory maneuvers. In contrast, spirometry requires a deep inspiration followed by a forced and complete expiration.
Oscillometry provides a measure of respiratory impedance, which is the complex sum of respiratory resistance (Rrs) and respiratory reactance (Xrs). However, when the oscillatory signal is applied directly at the subject's airway opening, part of the flow signal may be lost due to cheek wall vibrations, resulting in an underestimation of Rrs. This underestimation may be more pronounced during bronchoconstriction, such as that induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance. When calculating the response to ECT, cheek wall admittance is cancelled out, potentially allowing a more accurate assessment of changes in respiratory mechanics during an ECT.
The hypothesis was that calculating Ars provides a more accurate assessment of changes in airway mechanics during an ECT.
4,841 studies on the registry are indexed under Asthma; 600 are open to participants now.
This study's planned enrollment of 144 is close to the median of 158 across 1,250 observational studies indexed under Asthma.
Browse Asthma studies →Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.
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Data of children aged 5 to 16 years addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026 to the Pediatric Function Testing Department who have oscillometric and spirometric interpretable and reproducible measurements
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Exclusion Criteria:
Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of ≥ 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry)
Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of \< 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry)
Diagnostic performance of Ars
Area under the ROC curves (AUC) for response to exercise challenge of Ars (computed from oscillometric parameters) compared with AUC of respiratory resistance to identify children with a positive challenge test and children with a negative challenge test
Time frame: Through study completion, an average of 1 month
Sensitivity of Ars
Sensitivity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the sensitivity of respiratory resistance to identify children with a positive challenge test
Time frame: Through study completion, an average of 1 month
Specificity of Ars
Specificity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the specificity of respiratory resistance to identify children with a positive challenge test
Time frame: Through study completion, an average of 1 month
No study locations are listed for this record.
Plan to share: Undecided
Start is estimated for Aug 2026; primary completion for Aug 2026, 0 months later.
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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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