Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis

1. Men and women aged from 45 to 80 years
2. Fulfill criteria for knee osteoarthritis of the ACR - American College of Rheumatology (Altman et al., 1986)
3. Radiographic classification 2 or 3 by Kellgren and Lawrence score
4. Relate pain in the last week of 3 to 8 points on the Visual Analogue Scale - EVA (Bellamy et al., 1988)

Exclusion Criteria:

1. Use of analgesics, NSAIDs and myorelaxants less than a week before the start of the study.
2. Use of slow-acting drugs in osteoarthritis started less than 8 weeks before the start of the study. For cases that they have been in use for more than 8 weeks, they should be maintained until the end of the week.
3. Infiltration of corticosteroid or infiltration with hyaluronic acid in the six months prior to the start of the study.
4. Intra-articular infiltration with any medication in any other joint less than 1 month after inclusion;
5. Introduction of any medical or physiotherapeutic intervention in the last 3 months (rehabilitation, acupuncture, cane, orthotics, etc.) for locomotor system;
6. Body Mass Index (BMI) greater than 35.
7. Presence of other types of arthropathies such as rheumatoid arthritis, diffuse connective tissue diseases, microcrystalline arthropathies, spondyloarthropathies and infectious arthropathies.
8. Symptomatic osteoarthritis of hip and feet
9. Presence of known meniscal or symptomatic ligament damage in the studied knee;
10. Previous surgery in the studied knee.
11. Difference in length in lower limbs greater than 1 cm.
12. Presence of cutaneous lesion on the surface of the joint studied;
13. Important scoliosis.
14. Blood dyscrasia or use of anticoagulant;
15. Presence of other diseases: severe depression, diabetes, coagulopathies, decompensated cardiovascular disease, infection, immunosuppression (allowed MTX up to 10 mg), systemic infectious disease, symptomatic lower limb vascular disease, neurological diseases, neoplasia or any other conditions that may compromise the procedure in doctor evaluation;
16. To be receiving pension benefit due to osteoarthritis of the knees.