An observational study in Autoimmune Diseases and Chronic Lymphocytic Thyroiditis, sponsored by Centre Hospitalier Universitaire, Amiens. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-04-14.
Sponsored by Centre Hospitalier Universitaire, Amiens · Observational
Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.
Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.
It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.
Patients were recruited after PHRC 2005. Written information for the extension of the study will be sent with a copy of the summary of the scientific publication on Enterovirus (PHRC 2005).
Exclusion Criteria:
Other: Comparison of the prevalences of the parvovirus genome
Other: Comparison of the prevalences of the parvovirus genome
Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature
Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein
Time frame: 1 day
This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire, Amiens