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Status unknownNCT03072797BHASUpdated Apr 27, 2022

Beijing Hospital Atherosclerosis Study

An observational study in Atherosclerosis, Cardiovascular Diseases and Coronary Artery Disease, sponsored by Beijing Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-27.

Sponsored by Beijing Hospital · Observational

The sponsor has not verified this record recently (last verified Apr 2022), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,000
Ages
18 Years and older
Sex
All
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Study summary

The Beijing Hospital Atherosclerosis Study (BHAS) is a prospective, single-center, observational cohort study performed at the Beijing Hospital in Beijing, China. Subjects enrolled in this study will be the consecutive patients undergoing coronary angiography in the hospital. Blood samples are taken immediately before the angiographic procedure. Clinical and angiographic characteristics are recorded. All patients will have routine follow-up at 6 months and 1 year postprocedure, then yearly thereafter. Follow-up includes mortality, myocardial infarction (MI), stroke, rehospitalization, coronary revascularization procedures, life styles, and medication use. The primary end point for the study will be the major adverse cardiovascular events (MACE), defined as death from any cause, nonfatal myocardial infarction, nonfatal stroke and revascularization. This study has been reviewed and approved by the Ethics Committee of Beijing Hospital. All enrolled individuals will be received written notice of the intended use of their blood samples and provided written consent.

The major objectives of the BHAS Study are to (1) establish a prospective cohort and a biological sample bank in ethnic Chinese with coronary angiography, (2) identify baseline new biosignature profiles such as novel biomarkers via metabolomics approach associated with the subsequent clinical events, (3) assess the use of molecular profiles from multiple platforms (eg, genomics, proteomics, and metabolomics) integrated with readily available clinical information for improved risk classification for cardiovascular events, and (4) provide clearer understanding of underlying disease processes.

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Conditions studied

  • Atherosclerosis
  • Cardiovascular Diseases
  • Coronary Artery Disease
  • Myocardial Ischemia
  • Stroke

Keywords

  • Atherosclerosis
  • Longitudinal
  • Biomarker
  • Coronary angiography
  • Follow-up
  • Metabolomics
  • Risk factor
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's planned enrollment of 3,000 is above the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

Beijing Hospital is the lead sponsor of 51 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Subjects enrolled in this study will be the consecutive patients undergoing coronary angiography at the Beijing Hospital in Beijing, China.

Inclusion criteria

  • Age >18y
  • Consent for the study
  • Primary reason for catheterization is concern for ischemic heart disease
  • Complete clinical and coronary angiogram data available

Exclusion criteria

Exclusion Criteria:

  • Primary pulmonary hypertension or severe lung disease
  • Cardiac transplantation
  • Other solid organ transplant
  • Peripheral vascular intervention only
  • Right heart catheterization only
  • Advanced heart failure
  • Congenital heart disease
  • Women who are pregnant or nursing, or preparing for pregnant during the study period
  • Progressive fatal disease
  • History of alcoholism or drug abuse
  • Patients with mental illness and are being treated
  • Patients are undergoing radiotherapy or chemotherapy
  • Acute and chronic infectious diseases
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. Number of participants with major adverse cardiovascular events (MACE)

    MACE include death from any cause, nonfatal myocardial infarction, nonfatal stroke and revascularization.

    Time frame: 3 years

Secondary outcomes

  1. Number of participants with other atherosclerosis events

    Other atherosclerosis events include readmission for angin and transient ischemic attack.

    Time frame: 3 years

07

Study locations

1 of 1 sites recruiting
  • Bejing Hosptial
    Beijing, Beijing 100730, China
    • Ruiyue Yang, M.D. · Contact · yangruiyue4057@bjhmoh.cn · +861058115049
    • Wenduo Zhang, M.D. · Contact · zhangwenduo3103@bjhmoh.cn · +861085136232
    • Fusui Ji, M.D. · Principal investigator
    • Wenxiang Chen, M.D. · Principal investigator
    • Jun Dong, Ph.D · Sub investigator
    • Xue Yu, M.D. · Principal investigator
    • Ruiyue Yang, M.D. · Sub investigator
    • Wenduo Zhang, M.D. · Sub investigator
    • Siming Wang, Ph.D. · Sub investigator
    • Xinyue Wang, M.D. · Sub investigator
    Recruiting
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References and documents

Publications

  • Kip KE, Hollabaugh K, Marroquin OC, Williams DO. The problem with composite end points in cardiovascular studies: the story of major adverse cardiac events and percutaneous coronary intervention. J Am Coll Cardiol. 2008 Feb 19;51(7):701-7. doi: 10.1016/j.jacc.2007.10.034. PubMed 18279733 ↗
  • Ussher JR, Elmariah S, Gerszten RE, Dyck JR. The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease. J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870. doi: 10.1016/j.jacc.2016.09.972. PubMed 28007146 ↗
  • Yang R, Zhang W, Wang X, Wang S, Zhou Q, Li H, Mu H, Yu X, Ji F, Dong J, Chen W. Nonlinear association of 1,5-anhydroglucitol with the prevalence and severity of coronary artery disease in chinese patients undergoing coronary angiography. Front Endocrinol (Lausanne). 2022 Sep 5;13:978520. doi: 10.3389/fendo.2022.978520. eCollection 2022. PubMed 36133308 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 27, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03072797
Lead sponsor
Beijing Hospital
Responsible party
Fusui Ji, MD (Director, Department of Gerontological Cardiology, Beijing Hospital) — Principal investigator
First posted
Mar 7, 2017
Start date
Mar 16, 2017
Primary completion
Dec 31, 2022 (estimated)
Completion
Dec 31, 2022 (estimated)
Last update
Apr 27, 2022

Study contacts

Ruiyue Yang, M.D.
Contact
yangruiyue4057@bjhmoh.cn
+861058115049
Wenduo Zhang, M.D.
Contact
zhangwenduo3103@bjhmoh.cn
+861085136232
Fusui Ji, M.D.
principal investigator · Department of Cardiology, Beijing Hospital,National Center of Gerontology
Wenxiang Chen, M.D.
principal investigator · The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology
Xue Yu, M.D.
principal investigator · Department of Cardiology, Beijing Hospital,National Center of Gerontology

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

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