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Status unknownNCT03010514ARSGBTAADUpdated Jan 5, 2017

A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection

An observational study in Aortic Aneurysm, Thoracic and Aneurysm, Dissecting, sponsored by Beijing Institute of Heart, Lung and Blood Vessel Diseases. Status unknown at 1 site in China. Open to participants aged Up to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-01-05.

Sponsored by Beijing Institute of Heart, Lung and Blood Vessel Diseases · Observational

The sponsor has not verified this record recently (last verified Jan 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
600
Ages
Up to 80 Years
Sex
All
01

Study summary

This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection

02

Conditions studied

  • Aortic Aneurysm, Thoracic
  • Aneurysm, Dissecting
03

In context

Aortic Dissection

386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.

This study's planned enrollment of 600 is above the median of 183 across 180 observational studies indexed under Aortic Dissection.

Browse Aortic Dissection studies →

Lead sponsor

Beijing Institute of Heart, Lung and Blood Vessel Diseases is the lead sponsor of 23 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Up to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

case group consists of patients who was diagnosed as thoracic aortic aneurysm/dissection; control group is general population without aortic aneurysm/dissection

Eligibility criteria

Case Inclusion Criteria:

  1. Subject who was diagnosed as thoracic aortic aneurysm/dissection by CT angiography, interventional angiography or vascular ultrasound;
  2. Age is less than 80 years old;
  3. male and non pregnancy female;
  4. Subject understands study requirements aand agrees to sign an informed consent form prior to any study procedures.

Case Exclusion Criteria:

Subject has one of the following:

  1. Pseudoaneurysm;
  2. Previous infection or trauma in the damaged part of aorta;
  3. Pregnancy female;
  4. Participate in other clinical trials in the last 1 months.

Control Inclusion Criteria:

  1. Age and gender are matched with cases;
  2. No aortic disease was detected by outpatient ultrasound;
  3. No family history of cardiovascular disease;
  4. Normal biochemical indicators;

Criteria for culling, shedding and suspension testing:

  1. Culling: Unqualified cases and controls. Data of culled subjects can not be used for statistical analysis;
  2. Shedding: Subject that self withdrawal, loss to follow-up, or quitted by doctors; Reasons for shedding should be indicated for each shed subject.
  3. Suspension: a) The researchers found significant safety problems or wrong study design; b) Researchers cannot continue clinical research due to funding or management reasons; c) Director ends the study. When suspension happens, all the CRF table should be reserved for future reference.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
600 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • case
  • control
06

What researchers measure

Primary outcomes

  1. Age for each participant

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  2. Gender for each participant

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  3. Height for each participant

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  4. Weight for each participant

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  5. Contact information for each participant

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  6. Past Medical History including disease history, surgical history, and family medical history

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  7. Lifestyle including smoking history and drinking, specify how many years smoking or drinking lasted and detail quantity per day

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  8. Exon sequencing data of each participant

    Time frame: Sequencing will be carried out in an average of 3 months after sample recruiting

  9. Serum biomarker screening data of each participant

    Time frame: Screening will be carried out in an average of 3 months after sample recruiting

  10. The location of Aneurysm/Dissection

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  11. The size of Aneurysm/Dissection

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  12. blood biochemical index：blood lipid

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  13. blood biochemical index：blood glucose

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  14. blood biochemical index：uric acid

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  15. blood biochemical index：urea

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  16. blood biochemical index：creatinine

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  17. blood biochemical index：C reactive protein

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  18. blood biochemical index：d dime

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  19. Drug treatment

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  20. Surgery type

    Time frame: These data is collected from the cases' medical record in an average of 1 month after the sample recruiting

  21. Prognosis information: all-cause death

    Time frame: These data is collected during follow-up visit at 3/6/12 months after discharge

  22. Prognosis information: whether recidivation happened

    Time frame: These data is collected during follow-up visit at 3/6/12 months after discharge

  23. Prognosis information including: whether other related disease happened

    Time frame: These data is collected during follow-up visit at 3/6/12 months after discharge

07

Study locations

1 of 1 sites recruiting
  • Beijing Anzhen Hospital
    Beijing, 100029, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 5, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03010514
Lead sponsor
Beijing Institute of Heart, Lung and Blood Vessel Diseases
Responsible party
Sponsor
First posted
Jan 5, 2017
Start date
Oct 2016
Primary completion
Apr 2019 (estimated)
Completion
Oct 2019 (estimated)
Last update
Jan 5, 2017

Study contacts

Yulin Li, PHD
Contact
lyllyl_1111@163.com
Jie Du, PHD
study director · Beijing Anzhen Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.

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Other studies in this condition

Aortic Dissection→

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Beijing Institute of Heart, Lung and Blood Vessel Diseases

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