An interventional study of transcranial direct current stimulation in Depression, sponsored by Medical University of Vienna. Completed at 1 site in Austria. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-16.
Sponsored by Medical University of Vienna · Not applicable, Interventional, and Basic science
With this study we will be able to dose-dependently measure real-time glucose metabolism changes after non-invasively stimulating superficial parts of the dlPFC, a commonly used target in therapeutic tDCS applications. This will provide further insight if and how tDCS is capable to change one of most reliable parameters of brain metabolism.
With this study, we will be able to substantiate if regional and whole brain glucose metabolism is affected by tDCS, assess the amount of signal change in relation to different currents and measure differences in glucose metabolism under stimulation reactivity between healthy subjects and depressive patients. The objective is to investigate the changes of regional cerebral metabolic rate of glucose (rCMRglu) in the brain after transcranial direct current stimulation in healthy subjects and depressive patients. The design is a cross-sectional proof of principle study in 20 healthy subjects and 20 depressed patients. During the PET scan tDCS will be applied with varying stimulus intensity. Furthermore, subjects will undergo a second PET scan with single-blind sham stimulation in order to validate the effects of tDCS. rCMRglu will be quantified using voxel-wise and ROI-based approaches. Changes in rCMRglu associated with tDCS-application will be calculated with a general linear model in a ramp function of the task-specific glucose uptake, according to previous work in our group. Exploratory statistical testing will be done using a paired samples t-test between task and rest conditions.
8,057 studies on the registry are indexed under Depression; 1,643 are open to participants now.
This study's enrollment of 15 is below the median of 84 across 6,718 interventional studies indexed under Depression.
Browse Depression studies →Medical University of Vienna is the lead sponsor of 1,076 studies on the registry; 177 are open to participants now.
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Healthy controls:
Depressed Patients:
Current major depressive episode during unipolar major depression (MD) according to SCID-I (with HAMD>17) No other concomitant axis-I disease apart from anxiety disorder, which must be secondary to MD Standard antidepressant medication stable during the last 4 weeks
Exclusion Criteria:
Left-handedness
Stimulation at three different intensities during FDG-PET scan
Other: transcranial direct current stimulation
Comparator to active arm
Other: transcranial direct current stimulation
0.5 mA, 1mA, 2mA for 10 minutes each
FDG-rCMRglu
regional cerebral metabolic rate of glucose
Time frame: 70 minutes
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Medical University of Vienna