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CompletedNCT02977351Updated Nov 30, 2016

Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms

An interventional study of Non-surgical periodontal treatment in Atherosclerosis and Chronic Periodontitis, sponsored by Izmir Katip Celebi University. Completed. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-11-30.

Sponsored by Izmir Katip Celebi University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
20 Years to 60 Years
Sex
All
01

Study summary

Determine the relationship between the systemic indications of atherosclerosis by means of the change in the ratio of periodontopathogenic microorganisms following periodontal treatment of individuals who have been diagnosed with chronic periodontitis-atherosclerosis and for individuals who have been diagnosed with systemically healthy-chronic periodontitis.

Read the detailed description

It has been aimed in this study to compare 1) the change in periodontal status; 2) the change of the periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) in dental plaque samples, 3) the changes of the amounts of HDL, LDL, hs-CRP white blood cell levels (WBC), platelet levels (PLT), creatinine, and fibrinogen in serum samples; and 4) the correlation between periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) and HDL, LDL, hs-CRP WBC, PLT, creatinine, and fibrinogen in patients that have been diagnosed with atherosclerosis-chronic periodontitis and systemic healthy patients and patients diagnosed with chronic periodontitis, following non surgical periodontal treatment.

02

Conditions studied

  • Atherosclerosis
  • Chronic Periodontitis

Keywords

  • Periodontopathogenic microorganisms
  • Non-surgical periodontal treatment
03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's enrollment of 40 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

Izmir Katip Celebi University is the lead sponsor of 191 studies on the registry; 40 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • had no systemic disease,
  • had not used any antibiotics
  • had not used medications with an impact on the immune system,
  • had not received any periodontal and/or medical treatment within the last 6 months.

Exclusion criteria

Exclusion Criteria:

  • smokers of cigarettes or other tobacco products,
  • pregnant or breastfeeding,
  • non-stable cardiovascular condition.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Atherosclerosis

    Patients with atherosclerosis and chronic periodontitis

    Procedure: Non-surgical periodontal treatment

  • Active comparator
    Systemically healthy

    Patients with Systemically healthy and chronic periodontitis.

    Procedure: Non-surgical periodontal treatment

Interventions

  • ProcedureNon-surgical periodontal treatment
06

What researchers measure

Primary outcomes

  1. Periodontopathogenic microorganism levels

    Time frame: 1 year

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 30, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02977351
Lead sponsor
Izmir Katip Celebi University
Responsible party
Dr. A. Seckin ERTUGRUL (Principal Investigator, Izmir Katip Celebi University) — Principal investigator
First posted
Nov 30, 2016
Start date
Jan 2014
Primary completion
Jan 2015
Completion
Jan 2016
Last update
Nov 30, 2016

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.

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