A Phase 3 interventional study of Donepezil and Placebo in Osteoarthritis, Femoral Head Necrosis and Rheumatoid Arthritis, sponsored by RenJi Hospital. Status unknown at 1 site in China. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-30.
Sponsored by RenJi Hospital · Phase 3, Interventional, and Prevention
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase inhibitor can prevent the POCD after isoflurane anesthesia in aged mice. Donepezil is a commercial medicine used for the Alzheimer Disease, which is tolerable and has minimal adverse events. In present study a multi-center randomized case control study was conducted and we hypothesized that donepezil attenuate the POCD.
477 studies on the registry are indexed under Necrosis; 54 are open to participants now.
This study's planned enrollment of 550 is above the median of 55 across 315 interventional studies indexed under Necrosis.
Browse Necrosis studies →RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.
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Exclusion Criteria:
Placebo was administrated
Drug: Placebo
Donepezil (5mg/ day for 7 days) was administrated
Drug: Donepezil
Donepezil a cholinesterase inhibitor, 5mg(1 pill)/ day for 7 days Po, was administrated from the day before surgery.
Placebo, 1 pill/ day for 7 days Po, was administrated from the day before surgery.
The incidence of POCD 7 days(or before leaving hospital ) after surgery
Time frame: 7 days after surgery or before leaving hospital
The incidence of postoperative delirium after surgery
Time frame: 1 to 7 days after surgery
POCD incidence 1 months after surgery
Time frame: 1 months after surgery
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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RenJi Hospital