An observational study in Purpura, Thrombocytopenic, Idiopathic and Regulatory B Cells, sponsored by University Hospital, Brest. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-09-07.
Sponsored by University Hospital, Brest · Observational
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.
697 studies on the registry are indexed under Thrombocytopenia; 153 are open to participants now.
This study's enrollment of 36 is below the median of 120 across 183 observational studies indexed under Thrombocytopenia.
Browse Thrombocytopenia studies →University Hospital, Brest is the lead sponsor of 594 studies on the registry; 135 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with a Purpura, Thrombocytopenic, Idiopathic, in chronic phase (>12 months) and healthy volunteers as control residents in Brest town, France.
Exclusion Criteria:
Adults patients with chronic immune thrombocytopenia
Biological: Biological tests
Adults without immune thrombocytopenia
Biological: Biological tests
From the blood: B and T cells extraction then co-culture B and T cells and characterization of lymphocytes by flow cytometry
Regulatory B cells functionality
inhibition of T cells proliferation with co-culture B and T cells
Time frame: 1 week
Cytometry immunophenotyping of B and T cells
characterization of B and T cells by flow cytometry
Time frame: 1 week
Plan to share: No
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This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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University Hospital, Brest