An interventional study of Muscle Biopsy in Ischemia and Peripheral Artery Disease, sponsored by University Hospital, Angers. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-12-19.
Sponsored by University Hospital, Angers · Not applicable, Interventional, and Basic science
The purpose of this study is to evaluate the effect of muscle ischemia during claudication on mitochondrial function.
Comparison to patients with arterial disease but absence of lower limb claudication (Cardiac group) feasibility study.
Assess the feasibility of the study of micro-vascular function and mitochondrial on muscle sample (sartorius) in a group of arterial disease and non arteriopathy group.
Analysis of the activity of mitochondrial chain Immunochemistry of tissue markers
1,542 studies on the registry are indexed under Peripheral Arterial Disease; 282 are open to participants now.
This study's enrollment of 36 is below the median of 74 across 1,066 interventional studies indexed under Peripheral Arterial Disease.
Browse Peripheral Arterial Disease studies →University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
pad Patients referred for femoro popliteal bypass Muscle biopsy during surgery
Other: Muscle Biopsy
Patients referred for saphenous withdrawal for coronary bypass Muscle biopsy during surgery
Other: Muscle Biopsy
A distal and proximal biopsy of the sartorius muscles ( 0.5 cm3 each) will be performed during surgery for saphenous vein withdrawal (cardiac group) or arterial bypass (PAD group) The samples are then treated with neurovascular and mitochondrial biology laboratory. the activity of the complex 1 is analyzed and compared between the 2 groups.
Activity differences in mitochondrial complex I between the distal and proximal levy in group 1 and group 2.
Measurement of mitochondrial complex 1 activity (arbitrary units) on muscle biopsies by the laboratory of biochemistry. Comparison of the results observed on the same miuscle at the proximal level (assumed normal in both groups) and distal level (assumed ischemic in claudicants but not in cardiac patients without limb symptoms.
Time frame: 1 week
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2016. You cannot join it, but the record below documents what was studied.
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University Hospital, Angers