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CompletedNCT02766062Updated Jun 30, 2016

Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

An interventional study of metabolic syndrome in Postoperative Complications, sponsored by General Hospital of Ningxia Medical University. Completed. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2016-06-30.

Sponsored by General Hospital of Ningxia Medical University · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
94
Allocation
Randomized
Ages
60 Years and older
Sex
All
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Study summary

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Read the detailed description

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

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Conditions studied

  • Postoperative Complications

Keywords

  • Postoperative cognitive dysfunction
  • metabolic syndrome
  • propofol
  • sevoflurane
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In context

Metabolic Syndrome

1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.

This study's enrollment of 94 is above the median of 60 across 1,460 interventional studies indexed under Metabolic Syndrome.

Browse Metabolic Syndrome studies →

Lead sponsor

General Hospital of Ningxia Medical University is the lead sponsor of 102 studies on the registry; 39 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • aged ≥60 years;
  • ASAⅡor Ⅲ
  • noncardiac surgery and nonneural surgery

Exclusion criteria

Exclusion Criteria:

  • Mini Mental State Examination [MMSE] score too low
  • chronic alcoho and drug abuse
  • disturbed renal and liver function
  • history of a cerebrovascular accident
  • permanent ventricular pacing
  • preoperative cognitive deficits
  • lack of cooperation
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Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
94 participants (actual)

Study arms

  • Active comparator
    propofol group

    Patients with metabolic syndrome were randomly assigned to receive propofol anesthesia

    Other: metabolic syndrome

  • Active comparator
    sevoflurane group

    Patients with metabolic syndrome were randomly assigned to receive sevoflurane anesthesia

    Other: metabolic syndrome

Interventions

  • Othermetabolic syndrome

    metabolic syndrome

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What researchers measure

Primary outcomes

  1. Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group

    Time frame: up to 7days postoperatively

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No — safety

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 30, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02766062
Lead sponsor
General Hospital of Ningxia Medical University
Responsible party
Sponsor
First posted
May 9, 2016
Start date
Sep 2015
Primary completion
Apr 2016
Completion
May 2016
Last update
Jun 30, 2016

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2016. You cannot join it, but the record below documents what was studied.

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