A Phase 3 interventional study of sodium bicarbonate and Lidocaine in Local Anesthesia, sponsored by Masoud Saatchi. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-04-05.
Sponsored by Masoud Saatchi · Phase 3 and Interventional
The purpose of this prospective, randomized, double blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) in patients with mandibular first molar experiencing symptomatic
Several studies have been done by adding Sodium Bicarbonate to local anesthesia in dentistry based on the theory that the amount of local anesthetic in the free-base un-ionized form will decrease to provide greater lipid penetration of the nerve and this could be cause of the failure of local anesthesia injected into the inflamed tissue with low PH and conflicting results were obtained. But, there are no study that evaluate effect of increasing PH in periradicular tissue on hindrance of resistance channels with supplementary infiltration injection of Sodium Bicarbonate
302 studies on the registry are indexed under Pulpitis; 67 are open to participants now.
This study's enrollment of 100 is above the median of 62 across 275 interventional studies indexed under Pulpitis.
Browse Pulpitis studies →Masoud Saatchi is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Exclusion Criteria:
0.7 mL of 8.4% sodium bicarbonate \& 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
Drug: sodium bicarbonate · Drug: Lidocaine
Sterile distilled water \& 0.3 mL of 2% lidocaine with 1:100,000 epinephrine
Drug: Lidocaine · Drug: sterile distilled water
success rate of IANB in the mandibular first molar with symptomatic irreversible pulpitis
Time frame: Baseline
Heft-Parker visual analog scale recording of pain
Time frame: Baseline
Plan to share: No
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This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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