An observational study in Parkinson's Disease, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to participants aged 35 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-18.
Sponsored by University Hospital, Lille · Observational
The investigators prospectively enrolled 64 early PD patients (less than 3 years after the first symptom) in order to prospectively assess the natural history of non-dopaminergic symptoms.
Patients were evaluated at baseline and after 2 years in off drug condition. Clinical, psychological, neuropsychological evaluations, functional respiratory evaluation, swallowing video fluoroscopy, dysarthria, gait and axial disorders.
Patients with Parkinson's disease (PD) with early idiopathic ( ≤ 5 years of evolution )
Exclusion Criteria:
natural history of non dopaminergic signs
Other: observational study
natural history of non dopaminergic signs
dysarthria severity assessed by the BECD scale
BECD (French battery of clinical evaluation of the dysarthria) is a validated scale for qualitative assessment of dysarthria severity in neurological disorders, especially PD
Time frame: 2 years
respiratory insufficiency detection
pulmonary function tests include spirometry with standard spirometer and maximal inspiratory and expiratory flow volume curves . At least 3 reproductible F-V curves are necessary. Values of FCV, FEV, peak expiratory flow, peak inspiratory flow, forced expiratory flow, SNIP were measured 12 hours after last levodopa intake (off drug)
Time frame: 2 years
swallowing function
150 mL glass of water test video fluoroscopy of swallow in off drug condition face and profile incidences: qualitative analysis of oral, pharyngeal, aspiration if necessary blindly assessed by 2 ENT experts in PD
Time frame: 2 years
gait axial function (freezing)
SWS test rhythmic tests for differens imposed frequencies (upper lower limb and facial) kinematic analysis of gait parameters by VICON (oxford metrics)
Time frame: 2 years
Mattis scale
Time frame: 2 years
LARS scale
Time frame: 2 years
MADRS scale
Time frame: 2 years
PAS scale
Time frame: 2 years
MoCA
Time frame: 2 years
Genetic Polymorphisme
To evaluate of cognitive and profile correlation to the polymorphisms of COMT (catechol-O-methyltransferase: Val158Met COMT) of MAPT H1 / H2 (microtubule associated tau protein) and ApoE (Apolipoprotein-E-ε2, 3, 4 )
Time frame: 2 years
Plan to share: No
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University Hospital, Lille