An interventional study of Low Frequency EA and Medium Frequency EA in Stroke Sequelae, Deglutition Disorders and Acupuncture Therapy, sponsored by Kaili Chen. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-09-24.
Sponsored by Kaili Chen · Not applicable, Interventional, and Treatment
Among 54 studies in Deglutition Disorders with a site in China — 21 open to participants now, 23 under way, none of them phase 3. Deglutition Disorders · China.
Among the 54 studies in Deglutition Disorders with a site in China, this one is the 15th largest by planned enrollment of the 48 interventional ones, is one of 7 that started in 2026, is one of 39 with no phase, reaches primary completion later than 19 of the 22 other live ones, and was the 50th registered.
871 studies on the registry are indexed under Deglutition Disorders; 237 are open to participants now.
This study's planned enrollment of 102 is above the median of 60 across 578 interventional studies indexed under Deglutition Disorders.
Browse Deglutition Disorders studies →21 of the 54 studies in Deglutition Disorders with a site in China are open now, in 1 country. Each count lists the studies.
Of the 137 Deglutition Disorders studies recruiting now, 74 (54%) set no upper age limit and 27 (20%) stop at 75 or younger; 15 take children under 18; 19 take healthy volunteers.
This study: 18 Years to 80 Years · all sexes · no healthy volunteers.
The full table on the hub →54 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 7 started in 2026.
Median enrollment 71 across the 48 interventional studies, 35 across the 6 observational. Of the 17 that completed or were terminated, 0 (0%) have results posted.
1 of 54 have an industry lead sponsor. The 10 most frequent:
This is the only study on the registry with Kaili Chen as lead sponsor.
Kaili Chen has 1 study filed under Deglutition Disorders — fewer than ten, so there is no comparison to draw.
5 of the studies in Deglutition Disorders with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT03979235National Research Center for Rehabilitation Technical AidsDeveloping Effectiveness Evaluation and Therapeutic Programs of Rehabilitation | 2026-12 |
| NCT07894224Shanghai Pulmonary Hospital, Shanghai, ChinaDexmedetomidine Nasal Spray and Postoperative Sore Throat After Bronchoscopy | 2026-12-01 |
| NCT07184892Qilu Hospital of Shandong UniversityEffects of Different Modes of Action Observation Therapy on Swallowing Function After Stroke: a Study Based on fNIRS | 2027-01-05 |
| NCT07373028Zeng ChanghaoSimple Swallowing Training Program on Older Individuals in the Community | 2027-06 |
| NCT07894315First Affiliated Hospital of Fujian Medical UniversityEEG Feedback-Based Vagus Nerve Stimulation for Post-Stroke Dysphagia | 2027-11 |
Among the 54 studies in Deglutition Disorders with a site in China, from their registry updates:
This randomized controlled study in patients with post-stroke dysphagia aims to determine the optimal stimulation frequency of electroacupuncture of the suprahyoid muscles and to elucidate the underlying neural mechanisms. Participants will be assigned to low-frequency (2 Hz), medium-frequency (50 Hz), or high-frequency (100 Hz) electroacupuncture groups. Therapeutic efficacy will be assessed using the Kubota water-drinking test, videofluoroscopic swallowing study (VFSS), and ultrasonography to identify the optimal frequency. In parallel, diffusion tensor imaging (DTI) will be used to evaluate changes in fiber connectivity between swallowing-related cortical regions (bilateral precentral gyrus, insula, supramarginal gyrus, and frontal lobe) and the medullary nucleus tractus solitarius, thereby exploring neural network remodeling and providing mechanistic evidence to inform clinical practice.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive electroacupuncture on the suprahyoid muscles at a frequency of 2Hz. The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Device: Low Frequency EA
Participants will receive electroacupuncture on the suprahyoid muscles at a frequency of 50Hz.The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Device: Medium Frequency EA
Participants will receive electroacupuncture on the suprahyoid muscles at a frequency of 100Hz. The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Device: High Frequency EA
Electroacupuncture will be applied to the suprahyoid muscles. The stimulation frequency will be set at 2 Hz (Low Frequency). The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Also known as: Electroacupuncture (2Hz)
Electroacupuncture will be applied to the suprahyoid muscles. The stimulation frequency will be set at 50 Hz (Medium Frequency). The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Also known as: Electroacupuncture (50Hz)
Electroacupuncture will be applied to the suprahyoid muscles. The stimulation frequency will be set at 100 Hz (High Frequency).The intensity should be adjusted to the patient's tolerance, utilizing a discontinuous waveform. Treatment is administered once daily for 30 minutes, with a course cosisting of 7 sessions. A rest day is observed between courses, and the treatment is continued for a total of 6 courses.
Also known as: Electroacupuncture (100Hz)
Change in Water Swallow Test (WST) Score
The WST is a screening tool for dysphagia. It assesses the ability to swallow water and the presence of coughing or choking. Scores range from 1 to 5, with higher scores indicating more severe dysphagia. Improvement is defined as a decrease in the WST score.
Time frame: Baseline and Week 6 (End of treatment)
Change in Penetration-Aspiration Scale (PAS) Score via VFSS
The PAS is an 8-point scale used to describe the severity of penetration and aspiration events during a Videofluoroscopic Swallowing Study (VFSS). Lower scores indicate safer swallowing function.
Time frame: Baseline and Week 6 (End of treatment)
Hyolaryngeal excursion measured by Ultrasound
B-mode ultrasound will be used to measure the anterior and superior displacement distance of the hyoid bone and larynx during swallowing. Greater displacement indicates better function of the suprahyoid muscles.
Time frame: Baseline and Week 6 (End of treatment)
Changes in Fractional Anisotropy (FA) values of swallowing-related neural pathways
Diffusion Tensor Imaging (DTI) will be used to measure the Fractional Anisotropy (FA) values of white matter fiber tracts connecting the bilateral precentral gyrus, insula, supramarginal gyrus, frontal lobe, and the nucleus of the solitary tract. Higher FA values indicate better structural integrity of the neural network.
Time frame: Baseline and Week 6 (End of treatment)
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Dec 2026; primary completion for Dec 2028, 24 months later.
Of 288 non-industry interventional studies with no phase under Deglutition Disorders, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 39. This study's planned 24 months is above that.
Counting every sponsor, half of 297 studies reached it within 21 months; a quarter within 10 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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