An interventional study of Aerobic exercise training in Coronary Artery Disease (CAD) and Obstructive Sleep Apnea (OSA), sponsored by University of Sao Paulo General Hospital. Status unknown at 1 site in Brazil. Open to participants aged 35 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-16.
Sponsored by University of Sao Paulo General Hospital · Not applicable, Interventional, and Treatment
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive sleep apnea (OSA) will potentiate these responses. And, that the exercise training would decrease the chemoreflex response of MSNA in these patients.
Forty patients with coronary artery disease, with (n=20) and without (n=20) obstructive sleep apnea will be studied. A healthy control, age-paired group (n=10) will be also evaluated. The patients will be submitted to a polysomnography and randomized for clinical follow-up or exercise training for four months. It will evaluated the autonomic function, chemoreflex control of sympathetic activity during hypoxic and hypercapnic maneuvers, endothelial function and inflammatory markers.
2,162 studies on the registry are indexed under Sleep Apnea Syndromes; 290 are open to participants now.
This study's planned enrollment of 50 is close to the median of 53 across 1,386 interventional studies indexed under Sleep Apnea Syndromes.
Browse Sleep Apnea Syndromes studies →University of Sao Paulo General Hospital is the lead sponsor of 595 studies on the registry; 98 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Healthy control group for comparisons with coronary artery disease groups.
Clinical follow-up.
Aerobic exercise training.
Other: Aerobic exercise training
Clinical follow-up.
Aerobic exercise training.
Other: Aerobic exercise training
The patients will be submitted to four months of aerobic exercise training, three time a week.
Chemoreflex control of MSNA at rest and during exercise.
Chemoreflex control of MSNA will be measured by microneurography technique during the gas mixture known exposure at rest and during exercise
Time frame: baseline and after 4 months
Endothelial Function
Endothelial Function will be measured by markers present in blood samples.
Time frame: baseline and after 4 months
Neurovascular Control
Neurovascular Control will be measured by venous occlusion plethysmography technique during the exposure mixture of gases known at rest and during exercise.
Time frame: baseline and after 4 months
Inflammatory markers
Inflammatory markers will be measured by markers present in blood samples.
Time frame: baseline and after 4 months
Quality of Life
Quality of life will be measured by the questionnaire Short-Form Health Survey (SF-36).
Time frame: baseline and after 4 months
Anxiety Trait and State
Anxiety Trait and State will be measured by the Spielberger state trait anxiety inventory (STAI).
Time frame: baseline and after 4 months
Symptoms of Depression
The level of symptoms of depression will be measured by the Beck scale.
Time frame: baseline and after 4 months
Mood State
Mood State will be measured by the profile of mood states (POMS) scale.
Time frame: baseline and after 4 months
This study is status unknown, as verified in May 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Sao Paulo General Hospital