An interventional study of Glucose tolerance test and Fat tolerance test in Obesity, Insulin Resistance and Healthy, sponsored by Universität des Saarlandes. Completed at 1 site in Germany. Open to participants aged 40 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-05-06.
Sponsored by Universität des Saarlandes · Not applicable, Interventional, and Diagnostic
The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.
The metabolic response in plasma and urine, pre- and post-load tests in people with specific dietary lifestyles will be tested. This project will focus on fat and glucose induced changes of targeted metabolic pathways that have been related to diabetes and obesity risk.
6,570 studies on the registry are indexed under Obesity; 1,718 are open to participants now.
This study's enrollment of 60 is below the median of 77 across 5,084 interventional studies indexed under Obesity.
Browse Obesity studies →Universität des Saarlandes is the lead sponsor of 68 studies on the registry; 17 are open to participants now.
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Exclusion Criteria:
All participants will receive an oral standardized glucose tolerance test
Other: Glucose tolerance test
The same participants will receive an oral standardized fat load test
Other: Fat tolerance test
Standardized oral glucose tolerance test (75 g oral glucose) and blood collection before and 2hrs after the glucose load
Oral fat tolerance will be provided to fasting participants and blood samples will be collected before and 4 hrs after the fat load.
Plasma levels of branched chain amino acid
Time frame: Changes between baseline and 2 hours
Plasma Trimethylamin N-oxide
Time frame: Changes between baseline and 2 hours
Plasma glucose level
Time frame: Changes between baseline and 2 hours
Plasma glucose
Time frame: Changes between baseline and 2 hours
Plasma level of acetyl-CoA
Time frame: Changes between baseline and 2 hours
Plasma malonyl-CoA
Time frame: Changes between baseline and 2 hours
Plasma phosphatidylcholine
Time frame: Changes between baseline and 2 hours
Plasma insulin
Time frame: Changes between baseline and 2 hours
Plasma leptin
Time frame: Changes between baseline and 2 hours
Plasma Lactate
Time frame: Changes between baseline and 2 hours
Plasma pyruvate
Time frame: Changes between baseline and 2 hours
Plan to share: Undecided — will be decided at a later stage
No publications or documents are linked to this record.
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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Universität des Saarlandes