An interventional study of Neuropsychological assessment and Neurologic consultation in Progressive Multiple Sclerosis and Multiple Sclerosis, Relapsing-Remitting, sponsored by University Hospital, Montpellier. Terminated at 1 site in France. Open to participants aged 30 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-18.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Diagnostic
The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these differences with Clinical disability and cognitive disorder results.
The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs, and correlate these differences with Clinical disability and cognitive disorder results. The modification of the Diffusion Tensor Imaging are well known in these two groups, as well as their link with the occurrence of movement and cognitive disorder. The study of the vasoreactivity during MRI aims to confront our results to the available data sources.
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's enrollment of 70 is above the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria :
22 patients with Progressive Multiple Sclerosis will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Other: Neuropsychological assessment · Other: Neurologic consultation · Other: MRIs (with vasoreactivity testing)
22 patients with Multiple Sclerosis, Relapsing-Remitting will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Other: Neuropsychological assessment · Other: Neurologic consultation · Other: MRIs (with vasoreactivity testing)
22 healthy volunteers will be included and they get an Neuropsychological assessment and MRIs (with vasoreactivity testing)
Other: Neuropsychological assessment · Other: MRIs (with vasoreactivity testing)
A neuropsychological assessment is done
A neurologic consultation is done
MRIs (with vasoreactivity testing) is done
Cerebral vasoreactivity measured by diffusion imaging MRI (quantitative variable) :parameter which allow us to estimate the organization of the white matter tracts
Time frame: 2 months
Comparison of fonctional connective cards at Resting state
somatomotor network and default mode network
Time frame: 2 months
Cognitive disorders
Neuropsychological test results (quantitative and quantitative variable)
Time frame: 2 months
This study is terminated, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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University Hospital, Montpellier